工业真菌高效产酶突变技术与高产机制  

Recent Progress in Mutagenesis Strategies and High-yielding Mechanism for Enzyme Production in Industrial Fungi

作　　者：吕珊珊[1,2] 侯运华[1] 闫孟节 钟耀华[2] 

机构地区：[1]齐鲁工业大学生物工程学院,济南250353 [2]山东大学生命科学学院微生物技术国家重点实验室,济南250100

出　　处：《中国生物工程杂志》2016年第3期111-119,共9页China Biotechnology

基　　金：国家自然科学基金(31370135);国家"973"计划(2011CBOE07403)资助项目

摘　　要：工业真菌是酶制剂的重要生产微生物,其菌种改良具有重要应用价值。综述了产酶工业真菌的应用、突变育种技术进展和高效产酶机制的分析策略,尤其是基于组学水平的基因组、转录组和蛋白质组的分析等,最后总结了高产机制在菌株改良上的应用。Industrial fungi are economically important microorganisms used for enzyme production. Strain improvements towards these organisms have great application value. The application of the fungi for enzyme industry,the development of mutagenesis breeding technologies as well as the mechanisms for high-efficiency enzyme production,mostly derived from the genome-level analysis including genomics,transcriptomics and proteomics are introduced. The recent application of mutagenesis mechanisms for strain improvement also be summarized.

关 键 词：工业真菌 高效产酶 基因组学 转录组学 蛋白质组学 

分 类 号：Q814.9[生物学—生物工程]