ACECE基因插入/缺失多态性与运动员力量型运动能力关联性的Meta分析  

Association between the Insertion/Deletion Polymorphism of ACE Gene and Athletes' Sport Performance in Power Sports: A Meta-analysis

作　　者：艾金伟 刘盈[2] 李德胜[2] 刘羽[2] 裴斌[1,2] 

机构地区：[1]湖北医药学院附属襄阳医院循证医学中心,湖北襄阳441000 [2]湖北医药学院附属襄阳医院整形外科,湖北襄阳441000

出　　处：《中国循证医学杂志》2016年第3期263-269,共7页Chinese Journal of Evidence-based Medicine

基　　金：湖北省卫生计生西医类2015~2016年度一般项目(编号:WJ2015MB187)

摘　　要：目的系统评价血管紧张素Ⅰ转换酶(ACE)基因插入/缺失(I/D)多态性与力量型(爆发力)运动能力的相关性。方法计算机检索Pub Med、EMbase、CNKI、CBM、VIP和Wan Fang Data数据库,搜集关于ACE基因I/D多态性与力量型运动能力相关性的病例-对照研究,检索时限均为建库至2015年8月1日。由2位评价者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果最终纳入26个病例-对照研究,共计2 032例运动员和10 600例对照。Meta分析结果显示:ACE基因I/D多态性与力量型运动能力无相关性[DD vs.DI+II:OR=1.05,95%CI(0.81,1.36),P=0.70;DD+DI vs.II:OR=1.03,95%CI(0.82,1.29),P=0.80;DD vs.II:OR=1.04,95%CI(0.74,1.47),P=0.82;DI vs.II:OR=0.99,95%CI(0.81,1.22),P=0.96;D vs.I:OR=1.04,95%CI(0.88,1.24),P=0.62]。按种族进行的亚组分析结果显示,ACE基因I/D多态性与不同种族运动员力量型运动能力均无相关性。结论现有证据表明,ACE基因I/D多态性与运动员力量型运动能力之间不存在关联性。受纳入研究质量的限制,上述结论仍需进一步开展设计合理、方法得当的病例-对照研究或队列研究予以证实。Objective To systematically review the association between the insertion/deletion（I/D） polymorphism of angiotension-converting enzyme（ACE） gene and the athletes’ performance in power sports. Methods Databases including Pub Med, EMbase, CNKI, CBM, VIP and Wan Fang Data were searched up to August 1st, 2015 to collect casecontrol studies about the association between ACE I/D polymorphism and the athletes’ performance in power sports. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using Rev Man 5.3 software. Results A total of 26 case-control studies involving 2 032 athletes and 10 600 controls were included. The results of meta-analysis showed that no significant association was found between ACE I/D polymorphism and the athletes’ performance in power sports（DD vs. DI＋II： OR=1.05, 95%CI 0.81 to 1.36, P=0.70; DD＋DI vs. II： OR=1.03, 95%CI 0.82 to 1.29, P=0.80; DD vs. II： OR=1.04, 95%CI 0.74 to 1.47, P=0.82; DI vs. II： OR=0.99, 95%CI 0.81 to 1.22, P=0.96; D vs. I： OR=1.04, 95%CI 0.88 to 1.24, P=0.62）. Also, in subgroup analysis by ethnicity, no significant association was found between ACE I/D polymorphism and the performance of athletes of difference races in power sports. Conclusions Current evidence indicates that the ACE I/D polymorphism may not associate with the performance of athletes in power sports. Due to the quality limitations of included studies, more high quality case-control or cohort studies are needed to verify the above conclusions.

关 键 词：肽基二肽酶A 多态性 运动员 力量型运动 META分析 

分 类 号：R87[医药卫生—运动医学]