中药直肠滴入治疗糖尿病终末期肾病临床研究  

Clinical Study of Rectal Instillation Therapy of TCM in Treatment of Diabetes End Stage Renal Disease

作　　者：单留峰 郭丽芳[2] 

机构地区：[1]郑州市中医院,河南郑州450000 [2]河南省中医院,河南郑州450000

出　　处：《中医学报》2016年第3期357-359,共3页Acta Chinese Medicine

基　　金：河南省科技攻关项目(971200100)

摘　　要：目的:观察中药直肠滴入治疗糖尿病终末期肾病的临床。方法:将2011年9月—2014年6月郑州市中医院收治的60例糖尿病终末期肾病患者随机分为对照组和治疗组,每组各30例。对照组给予肾脏病常规治疗,治疗组在常规治疗基础上给予中药直肠滴入治疗。观察两组患者的临床疗效,比较两组患者治疗前后肾功能。结果:对照组有效率为66.67%,治疗组有效率为83.33%,两组患者有效率比较,差异具有统计学意义(P<0.05)。治疗组治疗后血尿素氮(blood urea nitrogen,BUN)为(11.43±6.18)mmol·L-1、肌酐(serum creatinine,SCR)为(248.28±143.7)μmol·L-1、肌酐清除率(creatinine clearance rate,CCR)为(37.13±21.35)mL·min-1,对照组BUN、SCR、CCR分别为(13.11±4.46)mmol·L-1、(273.38±80.68)μmol·L-1、(30.37±12.67)mL·min-1,与治疗前比较,差异均有统计学意义(P<0.05);治疗组治疗后明显优于对照组,差异亦有统计学意义(P<0.05)。结论:中药直肠滴入治疗糖尿病终末期肾病疗效显著。Objective： To observe the clinical efficacy of rectal instillation therapy of TCM in treatment of diabetes end stage renal disease（ ESRD）. Methods： 60 cases of diabetic ESRD patients from September 2011 to June 2014 in Zhengzhou Municipal TCM Hospital were randomly divided into control group and treatment group,with 30 cases in each group. The control group received conventional treatment of kidney disease,while the treatment group was given rectal instillation therapy of TCM besides that of the control. The clinical efficacy of the two groups of patients was observed and compared before and after treatment. Results： The clinical efficacy of the control group was 66. 67%,while that of the treatment group was 83. 33%. The difference between the two groups was statistically significant（ P 〈 0. 05）. After treatment,blood urea nitrogen（ BUN）,serum creatinine（ SCR）,and creatinine clearance rate（ CCR） of the treatment group was（ 11. 43 ± 6. 18） mmol · L- 1,（ 248. 28 ± 143. 7） μmol·L- 1and（ 37. 13 ±21. 35） mL ·min- 1respectively,while those of the control group was（ 13. 11 ± 4. 46） mmol·L- 1,（ 273. 38 ± 80. 68）μmol·L- 1and（ 30. 37 ± 12. 67） mL ·min- 1respectively. Compared with those before treatment the differences were statistically significant（ P 〈 0. 05）. The differences between those of the treatment group and the control group were also statistically significant（ P 〈0. 05）. Conclusion： Rectal instillation theory of TCM in treatment of diabetic endstage renal disease is clinically effective.

关 键 词：糖尿病终末期肾病 中药直肠滴入 大黄通腑合剂 血尿素氮 肌酐 肌酐清除率 

分 类 号：R259.872[医药卫生—中西医结合]