唾液标本检测肾小球滤过率计算机模块的临床对比研究  

The Clinical Comparative Study of the Computer Module for Glomerular Filtration Rate with Saliva Specimens

作　　者：邱艳娥[1] 吴锡信[1] 蔡旭[1] 童赟[1] 

机构地区：[1]广东省第二人民医院,广东广州510000

出　　处：《现代医院》2016年第2期202-203,206,共3页Modern Hospitals

基　　金：珠海市科委立项基金资助(编号:2003C104038)

摘　　要：目的吴氏创建了用唾液标本检测肾小球滤过率（GFR）智能检测分析系统（Sa GFRIDAS）的计算机模块,本研究探讨用该计算机模块测定的GFR的临床价值,并与99mTc-DTPA肾动态显像进行对比。方法随机选择本院肾内科2015年1月~2015年6月共60例慢性肾衰患者,分别通过唾液标本检测GFR的计算机模块和99mTc-DTPA清除率方法测定GFR（分别用Sa GFR、Tc GFR表示）,所得数据采用相关分析方法及bland-altman方法进行相关分析及一致性研究。结果两种方法测定之GFR相关系数为0.95（P=0.000）,t值为-1.603（P=0.114）;bland-altman法分析两种方法测定之GFR无显著差异。结论用唾液标本检测GFR计算机模块与通过99mTc-DTPA清除率方法测定GFR具有较高一致性,该模块具有准确、简便、快速、安全、廉价、无创的优点,可临床应用于反复检测GFR。Objective To study the clinical value of the computer module with saliva specimens developed by WU Xixin,and compared with 99 m Tc DTPA dynamic imaging. Methods 60 chronic renal failure patients were selected randomly,glomerular filtration rate were detected by the computer module with saliva specimens（ Sa GFR） and the determination of99 m Tc DTPA（ Tc- GFR）,All the results were processed with correlation analysis,and agreement analysis by bland- altman method. Results GFRs from those two methods were significantly associated（ r = 0. 95,P = 0. 000,t = 1. 603,P = 0. 114）;An acceptable agreement was found between them by bland- altman analysis. Conclusion There was a high consistency between the computer module using saliva specimens and the determination of 99 m Tc- DTPA. The module was an accurate and simple and celerity and safe and cheap and non- invasive method,can be repeatedly applied for clinical monitoring GFR.

关 键 词：唾液 肾小球滤过率 相关分析 bland-altman 

分 类 号：R446[医药卫生—诊断学]