纳洛酮和纳美芬与高压氧联合治疗急性重型颅脑损伤疗效观察  

Observation on Curative Effect of Naloxone and Naloxone Combine With Hyperbaric Oxygen in Treatment With Acute Severe Brain Injury

作　　者：韩东[1] 宋伟[1] 夏国庆[1] 张彦杰[1] 祝启海 

机构地区：[1]河南省焦作市第二人民医院神经外科,454150

出　　处：《中国继续医学教育》2016年第6期170-171,共2页China Continuing Medical Education

摘　　要：目的探讨急性重型颅脑损伤患者联合高压氧以及分别使用纳美芬、纳洛酮治疗的临床疗效。方法将68例急性重型颅脑损伤患者随机分为纳洛酮组和纳美芬组。纳洛酮组在常规治疗基础上静脉滴注盐酸纳洛酮注射液并且联合高压氧治疗,纳美芬组在常规治疗基础上静脉注射盐酸纳芙芬注射液并且联合高压氧治疗。观察两组治疗前与治疗后格拉斯哥评分以及3个月后GOS评分改善情况。结果与治疗前相比较,纳美芬组较纳洛酮组治疗14 d后格拉斯哥评分改善,差异有统计学意义(P<0.05);纳美芬组治疗3个月后临床症状优于纳洛酮组,差异有统计学意义(P<0.05)。结论纳美芬治疗急性重型颅脑损伤是较为合理的选择。Objective To investigate the acute severe brain injury patients and clinical efficacy of hyperbaric oxygen are using nalmefene, naloxone treatment. Methods Selected 68 patients with severe brain injury were randomly divided into groups of naloxone and nalmefene group. Naloxone group in the conventional treatment based on intravenous naloxone hydrochloride injection and hyperbaric oxygen therapy, nalmefene group in the conventional treatment based on intravenous injection. Nalmefene hydrochloride injection and hyperbaric oxygen therapy. Two groups were observed before treatment and after treatment and glasgow score 3 months after GOS score improvement. Nalmefene clinical treatment group after 3 months, after compared with before treatment, nalmefene group than naloxone treatment group 14 days, glasgow scores improved significantly, and the difference was statistically significant（P〈0.05）. Results Symptoms significantly better than naloxone group, the difference was statistically significant（P〈0.05）. Conclusion Nalmefene patients with severe brain injury is more reasonable choice.

关 键 词：急性重型颅脑损伤 高压氧 纳洛酮 纳美芬 

分 类 号：R651.15[医药卫生—外科学]