抗原非特异性T细胞对天然免疫炎性反应的调控  

Regulation of innate inflammation by antigen non-specific T cells

作　　者：陈海荣[1] 张超[1] 张胜源 王为红[1] 李舒然[1] 唐宏[1,2] 

机构地区：[1]中国科学院生物物理研究所感染与免疫重点实验室,北京100101 [2]中国科学院上海巴斯德研究所,上海200031

出　　处：《生命科学》2016年第2期137-145,共9页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金重大项目(81590760);国家自然科学基金国际(地区)合作研究项目(81220108018)

摘　　要：天然免疫是抵御微生物入侵的第一道防线,其稳态的建立与维持须受到精确调控。近期研究进展表明,传统意义上抗原特异性免疫细胞——T细胞,能够以抗原非特异的方式在天然免疫阶段调节炎性反应,并决定了机体对微生物的免疫应答稳态。因此,深入了解T细胞以及不同T细胞亚型对天然免疫炎性反应的调控机制,有助于绘制天然免疫新的调控网络,阐述炎性疾病的发病机制,并提供新的治疗策略。Innate immune response is the first line of defence against invaded pathogens, thus a precise regulation is required to establish and maintain such an innate homeostasis. Emerging evidence has shown that T cells, conventionally functioning in an antigen-specific manner, retains the capability of pathogenic antigen non-specific response, which fundamentally determines the outcome of innate inflammatory response to pathogen infections.Therefore, a better understanding of the mechanisms of how T cells respond and regulate innate inflammation helps to draw a novel regulatory network for innate-immunity, and provide a new dimension to understand the immune pathogenesis and immune intervention against infections.

关 键 词：抗原非特异性T细胞 炎性调控 天然免疫稳态 

分 类 号：Q786[生物学—分子生物学]