皮肤免疫系统功能性研究进展  

Functional research progression in skin immune system

作　　者：楼方舟[1] 王宏林[1] 

机构地区：[1]上海交通大学医学院上海市免疫学研究所,上海200025

出　　处：《生命科学》2016年第2期268-274,共7页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金面上项目(31570922)

摘　　要：皮肤作为人体最大的器官,也是人体免疫屏障的第一道防线。近期研究表明,皮肤并不是一个被动的免疫器官,它具有主动的免疫防御、免疫监视及免疫自稳功能,为皮肤免疫系统。皮肤共生微生物数量以万亿计,皮肤中T淋巴细胞数量是人体循环T细胞总量的2倍,皮肤相关疾病有1 000种以上,而皮肤中细胞成分与体液成分的互作机制十分复杂。现针对皮肤免疫系统功能进行研究成果的概述与待解问题的展望。Skin is not only the largest organ of human body, and also the first line of immune barrier against eternal environment. Recent studies have identified that skin is far more than a passive immune organ, as it owns the capacity of immune defense, immune surveillance and immune homeostasis, which leads to a more comprehensive concept： skin immune system. The number of skin flora is more than 1 trillion and T cells residing in normal skin are twice the number of circulating T cells. Furthermore, there are more than 1000 kinds of skin related diseases, while the crosstalk between skin cellular and humoral constituents is extremely complex. This review summarizes the current research progression in the function of skin immune system, and provides outlooks for enigmas remaining to be resolved in this field.

关 键 词：皮肤免疫系统 皮肤免疫功能 角质形成细胞 TRM细胞 

分 类 号：R334.5[医药卫生—人体生理学] R392[医药卫生—基础医学]