血清T-SPOT.TB检验与胸腔积液中癌胚抗原和腺苷脱氨酶含量在诊断结核性和癌性胸腔积液中的意义  

Diagnostic significance about the content of ADA,CEA in pleural effusion and serum T-SPOT. TB test between tuberculous and malignant pleural effusion

作　　者：陶章[1] 仇爱民[1] 张海林[1] 张建生[1] 唐余广[1] 

机构地区：[1]江苏省盐城市第三人民医院呼吸内科,江苏盐城224001

出　　处：《吉林医学》2016年第3期522-523,共2页Jilin Medical Journal

摘　　要：目的:探讨胸腔积液中腺苷脱氨酶(ADA)和癌胚抗原(CEA)含量和血清T-SPOT.TB检验在结核性和癌性胸腔积液诊断中的意义。方法:系统回顾分析2005年1月到2014年6月在我院就诊的40例诊断明确的胸腔积液患者。癌性胸腔积液组(癌性组)和结核性胸腔积液组(结核性组)各20例,对两组患者行胸水CEA、ADA检测和血清T-SPOT.TB检验。结果:结核组ADA含量67.83±7.56 U/L,明显高于癌性组,差异有统计学意义(P<0.05),癌性组CEA含量(531.9 8±86.46)ng/ml,明显高于结核组有显著性差异(P<0.05)。两组间血清T-SPOT.TB阳性率的比较:癌性组5%,结核性组90%。结论:检测胸腔积液ADA和CEA含量,同时检测血清T-SPOT.TB在结核性与癌性胸腔积液的鉴别诊断中有重要意义。Objective Diagnostic significance about the content of ADA,CEA in pleural effusion and serum T- SPOT. TB test between tuberculous and malignant pleural effusion. Method Systematic review analysis of 40 patients diagnosed with pleural effusion from 2005 in January to 2014 in June in our hospital. Malignant pleural effusion group（ Cancer Group） and tuberculosis pleural effusion group（ tuberculous group） were in 20 cases respectively and all patients in the two group for pleural effusion CEA,ADA content and serum T- SPOT. TB test were detected. Results ADA content in tuberculosis group was（ 67. 83 ± 7. 56）U/L,significantly higher than the cancer group,there was significant difference（ P〈0. 05）,and cancer of the of CEA content in tuberculosis group was（ 531. 9 8 ± 86. 46） ng/ml,significantly higher than that of tuberculosis group（ P〈0. 05）. The comparison between two groups of serum positive rate of T- SPOT. TB in cancer group： 5%,tuberculous group 90%. Conclusion Detection of ADA and CEA in pleural effusion and serum T- SPOT. TB test have an important significance in differential diagnosis of tuberculous and malignant pleural effusion.

关 键 词：结核性胸膜胸腔积液 癌性胸腔积液 ADA、CEA和血清T-SPOT.TB 

分 类 号：R521.7[医药卫生—内科学]