多个低b值DWI技术在心脏成像中的初步研究  

A Preliminary Study of the Cardiac Magnetic Resonance Multi-low-b DWI Technology

作　　者：刘明熙[1] 张挽时[1] 张子衡 孟利民[1] 龚万沣 刘洁[1] 方红[1] 王萍[1] 

机构地区：[1]空军总医院CT、MR科室,北京100142 [2]GE医疗北京磁共振研究中心,北京100176

出　　处：《中国医疗设备》2016年第3期42-47,共6页China Medical Devices

摘　　要：目的初步研究多个低b值DWI技术在心脏检查中的成像技术和成像特点。方法对符合入组和排除条件的已签署知情同意书的30例健康志愿者行3.0T CMR Cine电影、T2WI和多b值DWI序列扫描,探讨此序列临床应用的可行性,统计分析心肌在各节段、不同供血区、年龄和性别中有无差异,并讨论行DWI序列扫描时,选择何种b值能够更好地反映心肌血流灌注情况。结果当b=20、60 s/mm^2时,图像质量较好。健康志愿者各节段心肌ADC值不全相等(F=6.315,P<0.001)。左前降支供血区,右冠状动脉供血区和左旋支供血区ADC值有差异(F=27.804,P<0.001),分别为(0.01186±0.00422)mm^2/s,(0.01032±0.00333)mm^2/s和(0.00902±0.00248)mm^2/s。从基底部到心尖部,心肌平均ADC值无差异。结论多个低b值DWI技术在CMR检查中具有较好的可行性和可重复性。健康志愿者各节段心肌ADC值存在节段性差异。当b=20,60 s/mm^2(<100 s/mm^2)时,图像质量较好,可能提示此DWI图像可更好地显示心肌血流灌注特点,为今后选择合理b值进行相关研究提供参考。Objective To investigate the imaging technology and characteristics of cardiac magnetic resonance（CMR） multi-low-b DWI technology. Methods With a 3.0T magnetic resonance imaging（MRI） system, cardiovascular magnetic imaging, including MR Cine, T2 WI and multi-low-b DWI technology, was performed in 30 healthy volunteers who had given written informed consent to investigate the clinical feasibility of multi-low-b DWI technology and to explore whether ADC values in different segmental myocardium, different blood supply areas, different age-groups and gender were similar or not. A discussion was made on which b value should be selected to better reflect the perfusion of myocardium when using DWI technology to scan cardiac structure. Results The image quality of multi-low-b DWI technology was better when the b values were 20, 60 s/mm^2（b100 s/mm^2）. The study showed ADC values of some myocardial segments in healthy volunteers were different（F=6.315,P〈0.001）. ADC values of different blood supply areas were different（F=27.804,P〈0.001） as below： the ADC value of the left anterior descending branch was（0.01186±0.00422） mm^2/s; the ADC value of the right coronary artery was（0.01032±0.00333） mm^2/s; the ADC value of the left circumflex was（0.00902±0.00248） mm^2/s. Besides, myocardial ADC values were not different from base to apex. Conclusion The CMR multilow-b DWI technology is feasible and repeatable. Myocardial ADC values have regional variation. The image quality is better when the b values are 20, 60 s/mm^2（b100 s/mm^2） which indicates the images obtained through DWI technology can better reflect myocardial perfusion. The research provides relevant reference for choosing the appropriate b values in the future studies.

关 键 词：心脏磁共振 弥散加权成像 健康志愿者 

分 类 号：TP391.41[自动化与计算机技术—计算机应用技术]