^99Tcm-MIBI断层及同机CT融合显像在继发性甲状旁腺功能亢进症术前定位诊断中的价值  

Value of ^99Tc^m-MIBI tomography and registration with integrated CT in preoperative localization and diagnosis of secondary hyperparathyroidism

作　　者：张长明[1] 马欢[2] 张玉芳[1] 

机构地区：[1]山东省聊城市人民医院核医学科,252000 [2]北京大学第一医院核医学科,100034

出　　处：《中华内分泌外科杂志》2016年第1期23-25,共3页Chinese Journal of Endocrine Surgery

摘　　要：目的探讨99m锝-甲氧基异丁基异腈（technetium-99m methoxy isobutyl isonitrile，99Tc^m-MIBI）断层及同机CT融合显像在继发性甲状旁腺功能亢进症（secondary hyperparathyroidism，SHPT）术前定位诊断中的价值。方法28例SHPT静脉注射^99Tc^m-MIBI370MBq后15min行颈胸部平面显像，90min行延迟平面显像，结束后开始核素断层及CT融合显像。所有显像结果均与手术病理结果进行比较。结果^99Tc^m_MIBI双时相平面显像、99Tcm-MIBI核素断层及同机CT融合显像对SHPT病灶的检出率分别为53．3％和70．7％，2者差异有统计学意义（Х^2=5．903，P〈0．05）。同机CT融合显像可提供详细的解剖定位，为手术医师提供更多的信息。结论，^99Tcm-MIBI断层及同机CT融合显像较单纯的双时相平面显像对SHPT病灶的检出率有所提高，可提供更多的解剖信息．在SH胛的术前定位诊断中有较高的临床价值。Objective To evaluate the value of technetium-99m methoxy isobutyl isonitrile （^99Tc-MIBI） tomography and integrated CT in preoperative localization diagnosis of secondary hyperparathyroidism （SHPT）. Methods 28 patients with SHPT were selected. 15 minutes and 90 minutes （delayed images）after intravenous administration of ^99Fc^m-MIBI 370 MBq, static anterior planar images of the neck and chest were obtained. ^99Fc^m-MIBI tomography and integrated CT scan were acquired after the delayed imaging. The imaging findings were compared to the pathological results. Results The detection rate of SHPT lesions by ^99Fc^m-MIBI dua-phase imaging and ^99Fc^m- MIBI tomography and registration with integrated CT scan was 53.3% and 70.7% respectively. The difference had statistical significance（Х^2 =5.903, P〈0.05 ）. The fusion imaging with integrated CT can provide detailed anatomy data and more information for surgical doctors. Conclusion ^99Tc^m-MIBI tomography and registration with integrated CT scan can improve the detection rate of SHPT compared with ^99Tc^m-MIBI dua-phase imaging, provide more detailed anatomy data, and has high clinical value in preoperative localization and diagnosis of SHPT.

关 键 词：继发性甲状旁腺功能亢进症 ^99M锝-甲氧基异丁基异腈 单光子发射型计算机断层显像 融合显像 

分 类 号：R582.1[医药卫生—内分泌]