基于“伏毒损脉”理论解毒活血配方颗粒治疗糖尿病相关性心绞痛  

Jiedu Huoxue formula particles treating diabetes-associated angina based on “Fudu Sunmai”

作　　者：王新东[1,2,3] 张苏洁[1,2] 吴慧[1,2] 祁晓霞[3] 

机构地区：[1]南京中医药大学附属中西医结合医院心血管科,南京210028 [2]江苏省中医药研究院,南京210028 [3]南京中医药大学,南京210023

出　　处：《吉林中医药》2016年第3期244-248,共5页Jilin Journal of Chinese Medicine

基　　金：国家自然科学基金资助项目(81403386);中国中医科学院江苏分院课题(JSBY1316)

摘　　要：目的观察解毒活血配方颗粒对糖尿病相关性心绞痛(DAA)患者中医临床证候、心电图、血糖血脂、炎症因子、抗氧化应激因子和血栓因子的影响。方法 45例糖尿病相关性心绞痛患者随机分为试验组23例,对照组22例。治疗组给予解毒活血配方颗粒,对照组给予二甲双胍片治疗。疗程12周,观察2组患者用药前后中医证候积分、心电图变化,血清FBG、2h BG、Hb A1c、TC、TG、HDL-C、LDL-C、IL-1β、TNF-α、Hs-CRP、SOD、MDA、v WF、Ps的变化。结果治疗后中医证候疗效试验组优于对照组(P<0.05),ST段下移导联数、T波低平导联数和T波倒置导联数治疗后2组间比较、试验组前后比较差异均有显著统计学意义(P<0.01),试验组FBG、2h BG、Hb A1c、TC、TG、LDL-C治疗后均显著下降(P<0.01),IL-1β、TNF-α、Hs-CRP、MDA、v WF、Ps均显著下降、SOD显著升高(P<0.01)。治疗后2组间比较IL-1β、TNF-α、Hs-CRP、MDA、v WF、Ps下降和SOD升高试验组较对照组为优(P<0.05,P<0.01)。结论解毒活血配方颗粒有助于缓解DAA患者的中医临床症状,改善心电图,调节血糖、血脂,并可能通过抗炎、抗氧化应激、抗血栓途径发挥一定的心肌保护作用。Objective To observe effect of the Jiedu Huoxue formula particles on patients with diabetes-associated angina（ DAA）,by clinical syndromes of TCM,ECG,blood glucose and lipid,inflammatory factors,stress factors and thrombosis factors affecting antioxidant. Methods The 45 cases of patients with angina pectoris associated with diabetes were randomly divided into treatment group 23 cases,22 cases of the control group were given basic western medicine,on the basis of the test group was given Jiedu Huoxue formula particles,the control group received metformin treatment,treatment for 12 weeks,symptom scores were observed before and after treatment,ECG changes,serum FBG,2h BG,Hb A1 c,TC,TG,HDL-C,LDL-C,IL-1β,TNF-α,Hs-CRP,SOD,MDA,v WF,Ps changes. Results After treatment,TCM syndrome treatment group than the control group（ P〈0. 05）,ST segment depression in the number of leads,T wave flattening the number of leads and the T-wave inversion between the two groups after the treatment the number of leads,before and after the test group differences were statistically significant（ P〈0. 01）,the test group FBG,2h BG,Hb A1 c,TC,TG,LDL-C after treatment were significantly decreased（ P〈0. 01）,the test group therapy after IL-1β,TNF-α,Hs-CRP,MDA,v WF,Ps were significantly decreased,significantly increased SOD（ P〈0. 01）,after treatment between the two groups IL-1β,TNF-α,Hs- CRP,MDA,v WF,Ps decline and SOD increased treatment group than in the control group was superior（ P〈0. 05,P〈0. 01）. Conclusion Jiedu Huoxue formula particles can not only relieve symptoms in patients with DAA,improve ECG,lower blood sugar,regulate blood lipids,and can play a role in myocardial protection through anti-inflammatory,anti-oxidative stress,anti-thrombotic pathways.

关 键 词：伏毒损脉 解毒活血配方颗粒 糖尿病 心绞痛 炎症因子 抗氧化血栓相关因子 

分 类 号：R541.4[医药卫生—心血管疾病]