丹参煎剂对冠心病心绞痛患者血液流变学指标的影响  

Danshen decoction on hemorrheology in patients with coronary heart disease angina pectoris

作　　者：冷玉杰[1] 

机构地区：[1]辽宁中医药大学附属医院,沈阳110032

出　　处：《吉林中医药》2016年第3期249-252,共4页Jilin Journal of Chinese Medicine

基　　金："十二.五"国家科技支撑计划项目(2011BAT11B07);辽宁省科技厅项目(2012020108-201)

摘　　要：目的探讨中药丹参煎剂对冠心病不稳定型心绞痛患者疗效及对血液流变学指标影响的中药学临床研究。方法选取80例冠心病不稳定型心绞痛患者,随机分为治疗组和对照组,每组各40例。其中对照组采用硝酸甘油、阿司匹林、β受体阻滞剂等常规药物治疗,治疗组则在对照组的基础上给予中药丹参煎剂治疗。2组患者均以治疗10 d为1个疗程,治疗2个疗程。治疗结束后对比治疗前后患者临床疗效及血液流变学情况。结果经治疗观察2组患者临床症状改善情况,治疗组临床症状明显改善,总有效率为82.50%,对照组临床症状有所改善,总有效率为65.00%,2组对比差异有统计学意义(P<0.05);治疗后检测2组患者血液流变学指标均有所下降,治疗组下降更为显著,差异有统计学意义(P<0.05)。结论中药丹参煎剂具有活血化瘀、清心除烦、凉血消痈之功效,具有降低外周血管阻力,扩张血管以提高微循环,促进侧支循环,降低血黏度,抑制血凝的作用,可有效改善心脏循环,降低血液流变学指标。Objective To study the traditional Chinese medicine Danshen decoction on patients with unstable angina,and coronary artery disease on hemorrheology,the influence of traditional Chinese medicine clinical research of TCM. Methods Choose 80 cases of patients with unstable angina,coronary heart disease were randomly divided into treatment group and control group,40 cases in each group. The control group using nitroglycerin,aspirin,beta blockers and other conventional drug treatment; treatment group is in the control group,on the basis of giving traditional medicine Danshen decoction treatment. Two groups of patients to treat 10 days for a period of treatment,treatment 2 course of treatment. The contrast made before and after treatment in patients with clinical curative effect and blood rheology.Results The treatment of two groups of patients with clinical symptoms was observed,the clinical symptoms improved significantly the total effective rate was 82. 50%,while the control group clinical symptoms improved the total effective rate was 65. 00%,compared the two groups have significant difference,the difference was statistically significant（ P〈0. 05）; detection in the two groups after treatment in patients with hemorheology indexes has fell,but the treatment group decreased more significantly,the difference was statistically significant（ P〈0. 05）. Conclusion Chinese medicine Danshen decoction has the promoting blood circulation to remove blood stasis,clearing except vexed,the effect of anti cold blood,decrease peripheral vascular resistance,dilate blood vessels to improve microcirculation,promote collateral circulation,reduce blood sticky,inhibit blood clotting,which can effectively improve the cardiac cycle,reduce the blood rheology indexes.

关 键 词：丹参 冠心病 心电图 血液流变学 化瘀清心 通脉止痛 凉血消痈 

分 类 号：R541.4[医药卫生—心血管疾病]