右旋佐匹克隆与佐匹克隆治疗失眠症的系统评价  

Systemastic review of eszopiclon and zopiclon in treatment of insomnia

作　　者：杜彪[1] 谢星星 张杰[3] 范小冬 叶云 

机构地区：[1]重庆三峡中心医院,重庆404000 [2]四川医科大学,四川泸州646000 [3]川北医学院,四川南充637000

出　　处：《药物评价研究》2016年第1期112-115,共4页Drug Evaluation Research

基　　金：重庆市社会事业与民生保障科技创新专项计划项目(cstc2015shmszx120073);重庆市万州科技计划基金资助项目(201403055)

摘　　要：目的系统评价右旋佐匹克隆与佐匹克隆治疗失眠症患者的疗效及安全性。方法检索国内外科技期刊数据库,纳入右旋佐匹克隆、佐匹克隆治疗失眠症的随机对照试验,并进行Meta分析。结果共纳入7项研究1 021例患者,治疗2周后,2组睡眠障碍量表（SDRS）减分值比较差异无统计学意义[P=0.57,MD=0.77,95%CI（-1.88-3.41）];2组显效率差异无统计学意义[P=0.76,OR=0.96,95%CI（0.73-1.26）];2组头痛头晕、口干、口苦、恶心呕吐、嗜睡、上腹不适等不良反应发生率差异无统计学意义（P〉0.05）。结论右旋佐匹克隆与佐匹克隆治疗失眠症疗效及安全性相似。Objective To evaluate the differences in the efficacy and side effects between eszopiclon and zopiclon in the treatment of insomnia. Methods Randomized controlled trials assessing eszopiclon and zopiclon in the treatment of insomnia were retrieved from the domestic and foreign periodicals of science and technology database, and included in this Meta-analysis. Results Seven RCT involving 1 021 patients were identified. After 2 week, there was no statistically significant difference in SRDS subtraction score between two groups [P = 0.57, MD = 0.77, 95%CI（-1.88—3.41）]; There was no statistically significant difference showing the efficiency of two groups [P = 0.76, OR = 0.96, 95%CI（0.73—1.26）]; The main reactions such as headache dizziness, dry mouth, bitter mouth, somnolence, nausea, and vomiting in two groups had no statistically significant difference in incidence of epigastric discomfort（P〉0.05）. Conclusion Eszopiclon and zopiclon in the treatment of insomnia have a similar efficacy and safety.

关 键 词：右旋佐匹克隆 佐匹克隆 失眠症 系统评价 META分析 

分 类 号：R969.4[医药卫生—药理学]