骨质疏松症和动脉硬化关系的研究进展  

Correlation Between Osteoporosis and Arterial Stiffness

作　　者：范东伟[1,2] 陈仲强[2] 王宏宇[1] 

机构地区：[1]北京大学首钢医院,北京100144 [2]北京大学第三医院,北京100191

出　　处：《心血管病学进展》2016年第2期99-103,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(30801156,81071505);北京市石景山区科技计划项目

摘　　要：在老年人群中,骨质疏松症和动脉硬化很常见,且二者的发病率随年龄增长而明显上升。近年来研究显示骨质疏松症和动脉硬化的发病相关。动物实验结果显示,动脉硬化或者钙化过程复杂,类似正常的成骨过程。例如,像骨形成发生蛋白家族、基质Gla蛋白、骨保护素等蛋白或基因既在成骨过程中发挥重要作用,又在动脉硬化或钙化过程中起作用。还有一些因素,如氧化应激、炎症、脂代谢也发挥重要作用。此外,治疗骨质疏松症的一些药物对动脉硬化也有保护作用。综上所述,现从流行病学、发病机制和临床药物治疗三方面对骨质疏松症与动脉硬化疾病关系的新进展进行阐述。Osteoporosis and arterial stiffness,two multifactorial and degenerative diseases,accompany the aging process. Many studies have shown in the last years a possible correlation between arterial stiffness and osteoporosis. Animal studies show that arterial stiffness /calcification is a complex mechanism that involves similar pathways described in the normal bone osteogenesis. Genes and proteins like BMPs,MGP,osteoprotegerin play an important role at the bone level but are also highly expressed in the calcified vascular tissue. Other factors like oxidative stress,inflammation,lipids metabolism are involved in this complex process. Moreover,the medications used for treating osteoporosis also inhibit the arterial stiffness / calcification process. In this review,the recent progress of association between the two diseases in epidemology,physiopathology and treatment will be discussed.

关 键 词：骨质疏松 动脉硬化 血管钙化 

分 类 号：R580[医药卫生—内分泌] R543.5[医药卫生—内科学]