衰老与心律失常  

Aging and Arrhythmias

作　　者：赵靖华[1] 尚美生[1] 姚艳[1] 

机构地区：[1]北京市心肺血管疾病研究所首都医科大学附属北京安贞医院心内科,北京100029

出　　处：《心血管病学进展》2016年第2期121-124,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金项目(81200141);北京市科技新星计划(2011081)

摘　　要：衰老是多种心血管疾病发生发展的独立危险因素。随着老年化的进展,机体出现窦房结起搏细胞进行性减少,心肌细胞及间质纤维化明显增加,钠、钾、钙离子通道表达和功能异常,缝隙连接蛋白表达及分布异常,及由microRNA调控的心脏电重构等一系列心脏结构及电生理改变,心律失常的发病率和病死率显著增加,且针对老年性心律失常的防治亦有其特殊性,现就衰老与心律失常做一综述。Aging is an independent risk factor for the development of a variety of cardiovascular diseases. With the aging process,a series of cardiac structure and electrophysiological changes appear,such as progressive reduction of sinus pacemaker cells,significantly increasing fibrosis,Na~＋,K~＋,Ca^（2 ＋）channel dysfunction,the decline of connexins,and cardiac electrical remodeling regulated by microRNA. Arrhythmia morbidity and mortality increased significantly and the prevention and treatment of senile arrhythmia requires its own specific particularities. This paper gives a review of aging and arrhythmia.

关 键 词：心律失常 衰老 发病机制 治疗 

分 类 号：R541.7[医药卫生—心血管疾病]