干细胞来源的外泌体:心肌梗死治疗新启示  

Exosomes Derived from Stem Cells: Novel Approach in Treatment of Myocardial Infarction

作　　者：宋菲[1] 俞梦越 

机构地区：[1]北京协和医学院中国医学科学院阜外医院,北京100044 [2]中国医学科学院阜外医院,北京100044

出　　处：《心血管病学进展》2016年第2期125-129,共5页Advances in Cardiovascular Diseases

摘　　要：外泌体是在细胞间交流中起重要作用的外分泌纳米级磷脂双层囊泡,可由多种细胞分泌,在细胞间有效转运蛋白质、RNA等生命活性物质。值得注意的是,近期研究发现干细胞分泌的外泌体可以减少心肌细胞凋亡,促进心肌细胞、血管内皮细胞增殖分化,因而为心肌梗死提出了一种创新的生物分子治疗方式,现主要论述干细胞来源外泌体在治疗心肌梗死中的最新研究进展和对未来治疗应用的展望。Exosomes are nanosized secreted vesicles with phospholipid bilayers,which play important roles in cell-to-cell communication. Exosomes can be released by various cells and transport protein and RNA effectively between cells. Recent studies discovered that exosomes derived from stem cells exerted anti-apoptosis,cardiac regeneration and neo-vascularization effect,which are considered as novel molecular mechanisms of therapeutic potential of myocardial infarction. This review mainly summarizes the recent advances in research and discussed exosomes as a novel approach in the treatment of myocardial infarction in the future.

关 键 词：外泌体 干细胞 心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]