老年人血浆游离脂肪酸浓度、血糖水平与肥胖的关系  

Relationship Between Serum FFA,Blood Glucose and Obesity in the Elderly People

作　　者：陈兴国[1] 李英[1] 杨静[1] 李庆新[1] 

机构地区：[1]天津市泰达医院检验科,天津300457

出　　处：《标记免疫分析与临床》2016年第3期262-264,共3页Labeled Immunoassays and Clinical Medicine

基　　金：国家863基金子课题(2011AA02A111)

摘　　要：目的研究老年人血浆游离脂肪酸(FFA)浓度、空腹血糖水平与超重及肥胖的关系。方法对154例年龄≥60岁的志愿者,依据体重指数(BMI)分为肥胖组(41名)、超重组(39名)和正常体重组(74名),抽取空腹静脉血,检测血糖、胰岛素、血游离脂肪酸。结果肥胖组、超重组FFA均显著高于正常体重组(P<0.01)。肥胖组空腹血糖高于超重组、正常体重组(P<0.01),超重组空腹血糖高于正常体重组(P<0.01)。正常体重组、超重组FFA均与空腹血糖正相关(r:0.588、0.680,P均<0.05),与胰岛素敏感指数(ISI)负相关(r=:-0.387、-0.354,P均<0.05);肥胖组FFA与空腹血糖正相关(r=0.340,P<0.05),与胰岛素敏感指数(ISI)无相关(P>0.05)。在以FFA为应变量的多元回归方程中,空腹血糖、ISI进入方程(R^2=0.451,P<0.01)。结论血游离脂肪酸浓度与血糖水平相互影响,并与老年超重、肥胖密切相关。Objective To investigate the relationship between serum free fatty acid（ FFA） and glucose in the elderly people with over weight and obesity. Methods The people over 60 years old were selected and divided into obesity group（ n = 41）,over-weight group（ n = 39） and normal-weight group（ n = 74） according to the body mass index. The concentration of fasting blood-glucose,blood insulin and FFA were measured. Results The levels of FFA in obesity group（ 836. 9 ± 180. 4μmol / L） and over-weight group（ 779. 3 ± 150. 5μmol / L）were significantly higher than those in the normal-weight group（ 635. 5 ± 120. 6μmol / L）（ P〈0. 01）. The fasting blood-glucose levels in obesity group（ 6. 14 ± 0. 62 mmol / L） was significantly increased compared with over-weight group（ 5. 58 ± 0. 67 mmol / L） and normal-weight group（ 5. 18 ± 0. 79 mmol / L）（ P〈0. 01）. The FFA level was positively correlated with fasting blood-glucose（ r： 0. 588,0. 680,P〈0. 05） and negatively with insulin sensitivity index（ r：-0. 387,-0. 354,P〈0. 05） in normal-weight group and over-weight group. In the obesity group,the FFA level was positively correlated with fasting blood-glucose（ r = 0. 340,P〈0. 05）,but no correlation was detected between FFA and insulin sensitivity index（ P〉0. 05）. A multiple linear regression analysis showed that fasting blood-glucose and insulin sensitivity index had important effect on FFA（ R^2=0. 451,P〈0. 01）. Conclusion The serum level of FFA and fasting blood-glucose are influenced each other,which may be important factors in the pathogenesis of adiposis in over-weight and obesity elderly people.

关 键 词：肥胖 血糖 游离脂肪酸 老年 

分 类 号：R589.2[医药卫生—内分泌]