异维A酸联合中药与异维A酸单用治疗中重度痤疮的meta分析  

A meta-analysis on treatment efficacy of isotretinoin plus traditional Chinese medicine versus isotretinoin for moderate to severe acne

作　　者：张颂楠 王昊[2] 陈智勇[3] 赵启明[3] 周欣[1] 于倩[1] 毕新岭[1] 吴建华[1] 顾军[1] 

机构地区：[1]第二军医大学附属长海医院皮肤科,上海200433 [2]浙江大学生物系统工程与食品科学学院,杭州310058 [3]解放军117医院南京军区整形美容中心,杭州310013

出　　处：《中华灾害救援医学》2016年第3期141-144,共4页Chinese Journal of Disaster Medicine

基　　金：上海市科学技术委员会生物医药领域产学研合作项目(13DZ1930906);第二军医大学军事医学专项基金(2012)

摘　　要：目的比较异维A酸联合中药与异维A酸单用治疗中重度痤疮的治疗效果。方法计算机检索Pub Med数据库、Embase数据库、CENTRAL图书馆、中国知识资源总库(CNKI)、中文科技期刊数据库(重庆维普)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(Sino Med)。纳入比较异维A酸联合中药与异维A酸单用治疗中重度痤疮的治疗有效率的随机对照试验。结果纳入研究6项,共581例患者。meta分析结果显示,异维A酸联合中药组的临床有效率优于异维A酸单用对照组[相对风险度(relative risk,RR)=1.32,95%可信区间(confidence interval,CI)(1.20,1.44),P<0.05];临床治愈率也高于异维A酸单用对照组[RR=1.63,95%CI(1.36,1.97),P<0.05]。结论对中重度痤疮,异维A酸联合中药的治疗效果优于异维A酸单用。Objective To evaluate the treatment efficacy of isotretinoin plus traditional Chinese medicine versus isotretinoin for moderate to severe acne. Methods A review of randomized controlled trials with meta-analysis performed by searching databases of Pub Med,Embase, and Cochrane Central Register of Controlled Trials（CENTRAL）, China National Knowledge Infrastructurethe（CNKI）, VIP database（VIP）, Wan Fang Data, and Chinese biomedical literature database（Sino Med）. Randomized controlled trials comparing isotretinoin plus traditional Chinese medicine and isotretinoin therapies in patients with moderate to severe acne were eligible for inclusion. Results Six trials were analyzed,involving 581 moderate to severe acne patients. Meta-analysis showed that compared with isotretinoin,isotretinoin plus traditional Chinese medicine was found to be superior for clinical effective rate in moderate to severe acne [relative risk（RR）=1.32, 95% confidence interval（CI）=（1.20, 1.44）,P0.05]. Recovery rate of isotretinoin plus traditional Chinese medicine in moderate to severe acne was higher than isotretinoin[RR=1.63,95%CI（1.36,1.97）, P0.05]. Conclusions Isotretinoin plus traditional Chinese medicine is more effective than isotretinoin for treatment of patients with moderate to severe acne.

关 键 词：异维A酸 中药 中重度痤疮 

分 类 号：R75[医药卫生—皮肤病学与性病学]