肾炎四味片对慢性肾小球肾炎血清IL-2、IL-6和T淋巴细胞亚群水平的影响  

Effect of Shenyan Siwei Pian on serum IL-2,IL-6 and T lymphocyte subsets in patients with chronic glomerulonephritis

作　　者：陈建祥[1] 徐宏[1] 张敏[1] 

机构地区：[1]浙江省嘉兴市第一医院肾内科,嘉兴浙江314000

出　　处：《中国生化药物杂志》2016年第1期129-131,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨肾炎四味片对慢性肾小球肾炎血清IL-2、IL-6和T淋巴细胞亚群水平的影响。方法收集收治的慢性肾小球肾炎患者58例,随机分为对照组和实验组,每组各29例,在常规治疗基础上,对照组患者给予贝那普利治疗,实验组患者在对照组基础上给予肾炎四味片治疗,治疗结束后,对所有患者的血清IL-2、IL-6及T淋巴细胞亚群水平进行检测。结果治疗后,与对照组比较,实验组患者的血清IL-2水平较高(P<0.05);实验组患者的血清IL-6水平较低(P<0.05);实验组患者的静脉血CD3、CD4T细胞、CD4/CD8水平较高,CD8T细胞水平较低(P<0.05)。结论肾炎四味片能够显著提高慢性肾小球肾炎患者血清IL-2水平,降低血清IL-6水平,改善患者的免疫功能。Objective To analysis the effect of Shenyan Siwei Pian on serum IL-2,IL-6 and T lymphocyte subsets in patients with chronic glomerulonephriti. Methods 58 patients who were diagnosed with chronic glomerulonephriti were collected and randomly divided into experimental group and control group,29 cases in each group. On the basis of conventional treatment,patients in the control group received benazepril therapy,patients in the experimental group were treated with Shenyan Siwei Pian on the basis of the control group treatment,after the treatment,the serum levels of IL-2,IL-6 and T lymphocyte subsets were detected in all patients. Results After treatment,compared with control group,the serum level of IL-2 was higher in the experimental group（ P〈0. 05）; the serum level of IL-6 was lower in the experimental group（ P〈0. 05）; the levels of CD3,CD4 T cells and CD4 /CD8 were higher,and the level of CD8 T cells was lower in the experimental group（ P〈0. 05）. Conclusion The Shenyan Siwei Pian can increase significantly the serum level of IL-2,and reduce the serum level of IL-6 in patients with chronic glomerulonephriti,improve the immune function of patients.

关 键 词：肾炎四味片 慢性肾小球肾炎 IL-2 IL-6 T淋巴细胞亚群 

分 类 号：R692.3[医药卫生—泌尿科学]