丹参注射液对冠心病患者血清LPO、SOD、NO及MDA的影响  

Effects of salvia injection on serum LPO,SOD,NO and MDA in patients with coronary artery disease

作　　者：敖勇 罗杨 杨建 赵艳华 

机构地区：[1]重庆市九龙坡区中医院急诊科,重庆400050 [2]重庆市九龙坡区第二人民医院检验科,重庆400052

出　　处：《中国生化药物杂志》2016年第1期139-140,共2页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的观察研究丹参注射液对冠心病患者血清脂质过氧化物（LPO）、血清超氧化物歧化酶（SOD）、血清一氧化氮（NO）和丙二醛（MDA）的影响。方法选取重庆市九龙坡区中医院急诊科2014年1月~2015年5月收治疗的确诊为冠心病的患者共70例,按随机数字表法分为观察组和对照组各35例,对照组给予常规西药治疗,观察组在对照组的基础上给予中药丹参注射液治疗,随访并记录2组患者相关指标变化情况。结果 2组患者治疗前血清LPO、SOD、NO和MDA指标变化差异无统计学意义,治疗2周后与对照组比较,观察组患者LPO、MDA显著降低,SOD、NO显著升高（P〈0.05）。结论中药丹参注射液对冠心病患者的临床治疗效果确切,无明显副反应。Objective To observe the effects of salvia injection on serum lipid peroxide（ LPO）,superoxide dismutase（ SOD）,nitric oxide（ NO）and malonaldehyde（ MDA） in patients with coronary artery disease. Methods 70 patients with coronary artery disease from January 2014 to May 2015 were randomly divided into observation group and control group,35 cases in each group. The control group received conventional western medicine,and observation group received traditional Chinese medicine salvia injection on the basis of control group,patients of two groups were followed up and the related indicators were recorded. Results There were no significant difference between two groups in serum of LOP,SOD,NO and MDA pre-treatment. After twoweeks treatment,compared with control group,the serum LPO and MDA levels were lower,SOD and NO levels were higher in observation group（ P〈0. 05）. Conclusion Salvia injection has an exact effect in treatment of patients with coronary artery disease with no obvious adverse reactions.

关 键 词：丹参注射液 冠心病 LPO SOD NO MDA 

分 类 号：R541.4[医药卫生—心血管疾病]