益气利水中药治疗儿童原发性肾病综合征临床研究  

Clinical Research on Pediatric Primary Nephrotic Syndrome Treated with Qi-Replenishing and Diuresis-Inducing Chinese Medicine

作　　者：常英丽 常克[2] 周太光[3] 

机构地区：[1]内江市中医院,四川内江641000 [2]成都中医药大学附属医院,四川成都610000 [3]泸州医学院附属医院,四川泸州646000

出　　处：《河南中医》2016年第2期267-269,共3页Henan Traditional Chinese Medicine

摘　　要：目的:观察益气利水中药治疗儿童原发性肾病综合征(primary nephrotic syndrome,PNS)的临床疗效。方法:将100例PNS患儿随机分为观察组52例和对照组48例,对照组使用常规西医治疗方案,主要药物为泼尼松,观察组在对照组治疗的基础上给予益气利水中药治疗。观察两组水肿消退时间、蛋白尿转阴时间、维持缓解情况和6个月内复发率、感染率、6个月时泼尼松常用剂量,并检测相关指标的变化。结果:1观察组复发率、感染率以及6个月时泼尼松常用剂量小于对照组,两组比较有显著性差异(P>0.05);2治疗1个月、6个月,两组TC、TG、ALB均持续改善,各时段与本组治疗前比较均有显著性差异(P均<0.05),且观察组上述指标改善更明显,各时段与对照组同期比较均有显著性差异(P均<0.05)。3治疗6个月后,观察组CD4、CD8、CD4/CD8、CD3与Ig M、Ig G、Ig A水平均有所上升,与本组治疗前比较有显著性差异(P均<0.05);对照组除Ig G外其他指标与治疗前比较无显著性差异(P均>0.05);治疗6个月后,观察组T细胞亚群和免疫球蛋白与对照组比较均有显著性差异(P均<0.05)。4两组均未发现明显不良反应。结论:益气利水中药能调节PNS患儿免疫功能,减少感染率、复发率,减少糖皮质激素使用剂量,疗效显著。Objective： To observe the clinical effects of qi-replenishing and diuresis-inducing Chinese medicine on primary nephrotic syndrome（ PNS）. Methods： 100 cases with PNS were randomized into observation group（ 52 cases） and control group（ 48 cases）. Control group were given conventional western medicine treatment schedule and the main drug was prednisone while observation group were additionally given qi-replenishing and diuresis-inducing Chinese medicine. The time for edema abatement,time for proteinuria to become negative,condition of maintaining relief,relapse rate and infection rate within 6 months and dose of common usage of prednisone within 6 months were observed. And the changes of relevant indexes were examined. Results： The relapse rate,infection rate and dose of common usage of prednisone within 6 months in observation group were lower than these in control group; the difference had statistical significance（ P〈 0. 05）. After one month and 6 months of treatment,the levels of TC,TG and ALB in both groups got continuous improvement. And for each period of time in the same group,there was significant difference when compared with before the treatment（ P〈 0. 05）. For each period of time,the above indexes in observation group were improved more rapidly when compared with those in control group; the difference was significant（ P〈 0. 05）. After 6 months of treatment,the levels of CD4,CD8,CD4 / CD8,CD3 and levels of Ig M,Ig G and Ig A all increased; there was significant difference when compared with before the treatment（ P〈 0. 05）. Except for the level of Ig G,the other indexes in control group had no significant difference when compared with before the treatment（ P〉0. 05）. After 6 months of treatment,there was significant differences in T cell subset and immune globulin between observation group and control group（ P〈 0. 05）. There was no obvious adverse reaction in both groups. Conclusion： Qi-replenishing and diuresis-inducing Chinese medicine can regulate t

关 键 词：原发性肾病综合征 益气利水中药 泼尼松 

分 类 号：R259.926[医药卫生—中西医结合]