人体二尖瓣瓣膜厚度有限元分析及其仿真  

Simulation and Research on Thicknesses of Human Mitral Valves

作　　者：王聪[1,2] 黄晓阳[1,2] 苏茂龙 

机构地区：[1]福建省智慧城市感知与计算重点实验室(厦门大学) [2]厦门大学信息科学与技术学院,福建厦门361005 [3]厦门市心血管病医院,福建厦门361004

出　　处：《厦门大学学报（自然科学版）》2016年第2期272-277,共6页Journal of Xiamen University：Natural Science

基　　金：国家自然科学基金(61102137;61271336);福建省自然科学基金(2014J01438)

摘　　要：建立了基于亚区结构的人体二尖瓣模型,对二尖瓣从开放到闭合的整个过程进行仿真,分析心动周期过程中二尖瓣前后叶的应力分布差异,证实该有限元模型与实际生理相符.在该模型的基础上建立11个具有不同瓣膜厚度的比对模型,对比不同瓣膜厚度下二尖瓣的应力分布情况,分析瓣膜厚度对二尖瓣闭合程度的影响.实验结果表明随着二尖瓣瓣膜厚度增加,其整体应力水平虽然下降,但影响了二尖瓣性能的正常发挥,加重了二尖瓣关闭不全,同临床实际生理情况相吻合.实验结果验证了二尖瓣瓣膜厚度对二尖瓣应力分布具有较大影响,为更深入的研究和了解二尖瓣工作机制奠定了基础.A model based on the mitral valve sub-region has been established to simulate the process of early systolic pressure ramp.Stress distribution of anterior and posterior and the morphological motion state at different times have been shown.Results show that the finite element model is correct.On the basis of that model,11 models have been developed to compare the stress distribution and closure state under different thicknesses of the mitral valve.With the increasing of thickness,the overall stress decreasesbut the normal functioning mitral valve performance is affected,resulting in the aggravation of mitral regurgitation.The result is consistent with characteristics of the mitral hypertrophy.It further shows that the thickness of mitral valve exerts a great impact on the cardiac process,and lays the foundation for further studies of mitral valve.

关 键 词：二尖瓣 有限元分析 瓣膜厚度 应力分布 

分 类 号：TP391[自动化与计算机技术—计算机应用技术]