苍艾挥发油-羟丙基-β-环糊精包合物的制备及其表征  

Preparation and Identification for HP-β-cyclo Dextrin Inclusion Compound of Cang Ai Volatile Oil

作　　者：黄秋艳[1] 熊磊[1] 汪红梅[1] 马云淑[1] 陈柏君[1] 孔淑君 

机构地区：[1]云南中医学院,云南昆明650500

出　　处：《云南中医学院学报》2016年第1期27-30,42,共5页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81160534)

摘　　要：目的制备苍艾混合挥发油的羟丙基-β-环糊精(β-CD)包合物并且对其进行鉴别。方法以苍艾挥发油的包合率和包合物收得率作为综合评价指标,对饱和水溶液法,采用正交试验优选包合工艺条件;通过差示扫描量热分析仪法(DSC)、紫外扫描(UV)以及薄层色谱法(TLC)对包合物进行分析。结果最佳包合工艺:挥发油与羟丙基-β-环糊精投料比为1∶15(m L∶g),包合温度40℃,搅拌时间3 h,DSC及TLC均显示挥发油与β-CD已形成包合物。结论优选包合工艺可行,苍艾挥发油经包合后,溶解度及稳定性得到了改善;综合评价指标可作为工艺筛选指标和制剂质量的控制依据。Objective To prepare and identify HP-β-cyclo dextrin（β-CD）inclusion compound of Cang Ai volatile oil.Methods With the inclusion rate of Cang Ai volatile oil-β-CD complex and the yield of volatile oil HP-β-CD complex as evaluating indicators,saturated water solution method was investigated. Orthogonal design was used to select the optimum formulation. The volatile oil HP-β-CD complex was identified by DSC,UV and TLC. Results The optimum inclusion conditions were as follows：volatile oil：HP-β-CD in proportion as 1∶15（m L∶g）,inclusion temperature of 40℃,mixing time of 3h,analysis results of DSC and TLC showed that stable inclusion compound has been formed from volatile oil and HP-β-CD. Conclusion The optimum condition for inclusion was feasible,solubility and stability which were improved after incusing by HP-β-CD. The comprehensive evaluating indicators may provide scientific basis for both screening the technological process and quality control.

关 键 词：苍艾挥发油 羟丙基-Β-环糊精 正交试验 

分 类 号：R284.2[医药卫生—中药学]