普特彼对白癜风患者皮肤组织液ET-1和SCF的影响  

Influence of Protopic(tacrolimus) on expression of vitiligo skin tissue fluid of patients with ET-1 and SCF

作　　者：朴冰[1] 栗玉珍[2] 魏烨平[1] 王政礼 王洋洋[1] 崔英[1] 王丽梅[1] 

机构地区：[1]齐齐哈尔市第一医院皮肤科,黑龙江161006 [2]哈尔滨医科大学附属第二医院

出　　处：《齐齐哈尔医学院学报》2016年第6期701-702,共2页Journal of Qiqihar Medical University

基　　金：2014年齐齐哈尔科技局立项课题

摘　　要：目的探讨普特彼(他克莫司)对白癜风患者皮肤组织液中ET-1和SCF的表达的影响,为进一步明确普特彼治疗白癜风的作用机理奠定基础。方法采用ELISA法检测70例白癜风患者在普特彼治疗前后白斑和非白斑部位皮肤组织液中ET-1和SCF水平。结果白斑皮肤组织液中ET-1和SCF水平明显高于非白斑部位,差异有统计学意义。结论普特彼能促进角质形成细胞分泌ET-1和SCF,从而诱导黑素细胞的形成。Objective To investigate Protopic（ tacrolimus） on the expression of vitiligo skin tissue fluid of patients with ET-1 and SCF,and lay the foundation for further clarify the mechanism of Protopic treatment of vitiligo. Methods 30 cases of vitiligo patients before and after treatment with Protopic white and non-white parts of the skin tissue fluid ET-1 and SCF levels by ELISA. Results White skin tissue fluid ET-1 and SCF levels were significantly higher than non-white parts,the difference was statistically significant. Conclusions Protopic can promote keratinocytes secrete ET-1 and SCF,thereby inducing the formation of melanocytes.

关 键 词：白癜风 内皮素-1 干细胞因子 皮肤组织液 普特彼 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]