microRNAs在心肌梗死中的研究进展  

Research progress on microRNAs in myocardial infarction

作　　者：王丽平[1] 

机构地区：[1]兰州大学第二医院急救中心心电图室,兰州730030

出　　处：《临床心血管病杂志》2016年第3期217-220,共4页Journal of Clinical Cardiology

摘　　要：microRNAs(miRNAs)是一种非编码小分子RNA,通过降解mRNA或阻碍其翻译调控基因的表达。心肌梗死是一种常见的心血管疾病,导致心脏重构,最终发展为心力衰竭。miRNAs在心肌梗死的病理生理发展过程中起着重要作用,其可以促进或抑制心肌细胞凋亡,调控心肌细胞增,调节血管再生,此外还能调控心脏成纤维细胞重编程为心肌细胞。本文将综述miRNAs在心肌梗死中的最新进展和治疗前景。MicroRNAs（miRNAs）are small noncoding RNAs which could regulate gene expression by translation or induce degradation of mRNA.Myocardial infarction is a common cardiovascular disease that results in cardiac remodeling and leads to the development of heart failure.Several miRNAs have been shown to control important processes of the pathophysiological of myocardial infarction.MiRNAs can promote or inhibit cardiomyocyte cell death,control cardiomyocyte proliferation,and regulate neovascularization.Moreover,miRNAs also involve in the reprogramming of cardiac fibroblasts into cardiomyocytes.In this review,we focus on the current research progress of the role of miRNAs and discuss the therapeutic potential of miRNAs in myocardial infarction.

关 键 词：MICRORNAS 心肌梗死 研究进展 

分 类 号：R542.2[医药卫生—心血管疾病]