新疆维吾尔族、汉族新发心房颤动患者microRNA-328的表达水平  

Expression of microRNA-328 in patients with new onset atrial fibrillation of Uygur and Han nationality in Xinjiang

作　　者：方志敏[1] 吴庆[1] 陆云[1] 刘顺民[1] 赵海燕[1] 钟小兰[1] 宋宏雁[1] 班努.库肯 刘超群[1] 

机构地区：[1]新疆医科大学第二附属医院心内科,乌鲁木齐830063

出　　处：《临床心血管病杂志》2016年第3期225-227,共3页Journal of Clinical Cardiology

摘　　要：目的:比较microRNA-328在新疆维吾尔族及汉族新发心房颤动(AF)患者和窦性心律者中的表达水平。方法:收集2014-01-2015-06在新疆医科大学第二附属医院新发AF患者37例的病历资料,采用实时荧光定量聚合酶链反应(qRT-PCR)检测microRNA-328,比较血浆中的microRNA-328表达水平。结果:窦性心律组和新发AF组microRNA-328表达水平差异有统计学意义(P<0.01)。将维吾尔族和汉族作为协变量分层,比较窦性心律组和新发AF组microRNA-328表达水平的差异,结果显示维吾尔族、汉族microRNA-328表达在窦性心律组和新发AF组中均差异有统计学意义(P<0.01),不同民族表达具有一致性。结论:新发AF患者血浆microRNA-328表达水平增高,无论在维吾尔族或汉族患者中均具有一致性,提示microRNA-328可作为新发AF的生物标志物。Objective：To compare the expression level of microRNA-328 in Xinjiang Uygur and Han patients with new onset atrial fibrillation（AF）and sinus rhythm.Method：A total of 37 cases with new AF in the Second Affiliated Hospital of Xinjiang Medical University from January 2014 to June 2015 were included.Real-time fluorescence quantitative polymerase chain reaction（QRTPCR）was used to detect microRNA-328 plasma expression level.Result：There was significant difference in microRNA-328 expression between sinus rhythm group and AF group（P〈0.05）.The expressions of microRNA-328 in sinus rhythm group and AF group were statistically significant both in Uygur and Han patients（P〈0.05）.Conclusion：The plasma expression level of microRNA-328 is increased in new AF both in Uygur and Han patients,suggesting that microRNA-328 can be used as a biological marker of new onset AF.

关 键 词：心房颤动 microRNA-328 聚合酶链反应 

分 类 号：R541.7[医药卫生—心血管疾病]