Tim-3/Gal-9通路在免疫相关疾病中的研究进展  

Research Progress of Tim-3/Gal-9 Pathway in the Immune Related Diseases

作　　者：曾放[1] 刘顺[1] 孙科明 吴红学[1] 孙华文[1] 

机构地区：[1]武汉大学人民医院胃肠外科,武汉430060

出　　处：《医学综述》2016年第6期1044-1047,共4页Medical Recapitulate

基　　金：国家自然科学基金(81170368)

摘　　要：免疫反应在各种疾病的发生、发展以及转归中发挥着重要作用,T免疫球蛋白及黏蛋白分子3(Tim-3)是近年来新发现的一种免疫细胞1型细胞表面分子,与配体Galectin-9(Gal-9)结合后对机体的免疫细胞尤其是辅助性T细胞1(Th1)的定位、分化趋势及分泌功能等产生影响,从而改变机体正常的免疫功能,对相关疾病的发生起到延缓或促进作用。该文总结了Tim-3/Gal-9通路在自身免疫性疾病、移植免疫、抗感染免疫以及肿瘤免疫中的作用。The immune response plays an important role in the occurrence,development and outcome of various diseases. The T-immunoglobulin and mucin-3（ Tim-3） is a newly found surface molecule of immune cell type-1 in recent years. It can alter the normal immune function of body,delay or promote the occurrence of related diseases due to its combination with a widely distributive ligand Galectin-9（ Gal-9）,influencing the orientation,the differentiation tendency and the secretion function of the immune cells,especially Th1 cell.Here is to make a review of the impact of Tim-3 / Gal-9 on autoimmune diseases,transplantation immunity,anti-infection immunity and tumor immunity.

关 键 词：T细胞免疫球蛋白及黏蛋白分子3 GALECTIN-9 免疫 辅助性T细胞 

分 类 号：R392.12[医药卫生—免疫学]