NGAL作为急性肾损伤生物标志物的研究现况  

Current Research about Neutrophil Gelatinase-associated Lipocalin as A Biomarker of Acute Kidney Injury

作　　者：吴颖 何再明 

机构地区：[1]上海市普陀区利群医院急诊医学科,上海200333

出　　处：《医学综述》2016年第6期1058-1061,共4页Medical Recapitulate

基　　金：上海市普陀区科技自主创新自主项目(KW-2014-01)

摘　　要：急性肾损伤是临床上常见的危重症。近年来研究证实,人类中性粒细胞明胶酶相关脂质运载蛋白(NGAL)是预测和早期诊断急性肾损伤较为理想的生物标志物。NGAL具有能较早地出现于肾损伤的可逆阶段、与肾损伤程度呈剂量依赖性、很少被血液净化技术清除等优点;但同时,由于NGAL临界值范围较为宽泛、无权威指南明确指出NGAL的临床意义以及由于检测平台不同而导致检测结果存在差异等问题,也不容忽视。Acute kidney injury is a critical illness in clinical. In recent studies,it has been confirmed that the human neutrophil gelatinase-associated lipocalin（ NGAL） is a relatively ideal biomarker for prediction and early diagnosis of acute renal injury. There are a lot of advantages about NGAL： it can be earlier expressed in the reversible stage of kidney injury; the concentration of urine NGAL or plasma NGAL is in a dose-dependent relationship,that is proportional to the degree of damage; it is rarely cleared by renal replacement technology. While there are also some problems that can＇ t be ignored： the cut-off range of NGAL is broad; there is no published authorative guidelines about NGAL＇ s clinical significance; variability may exist between NGAL assays on different platforms.

关 键 词：急性肾损伤 中性粒细胞明胶酶相关脂质运载蛋白 生物标志物 

分 类 号：R446[医药卫生—诊断学]