血栓通联合前列地尔治疗下肢动脉硬化闭塞症的有效性及对其血液流变学的影响  

Effectiveness of Xueshuantong Combined with Prostaglandin E1 in Treatment of Peripheral Arterial Disease and Effect on Blood Rheology

作　　者：李建鹏[1] 王峥[2] 

机构地区：[1]河南省中医院,郑州450002 [2]河南中医药大学第一附属医院,郑州450000

出　　处：《中国实验方剂学杂志》2016年第6期159-162,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省科技攻关项目(122102310166)

摘　　要：目的:观察血栓通联合前列地尔治疗下肢动脉硬化闭塞症(PDA)的有效性及对患者血液流变学的影响。方法:按随机数字将2013年7月—2014年6月在河南省中医院治疗的91例PDA患者分为治疗组(46例)和对照组(45例),治疗组采用血栓通联合前列地尔治疗,对照组采用前列地尔治疗,治疗后观察两组疗效,并观察两组治疗前后踝肱指数(ABI),趾肱指数(TBI),足背动脉血流量,血流动力学指标。结果:治疗前两组患者年龄,性别,Fortain分期,体重指数,下肢病变部位,ABI,TBI,足背动脉血流量,肿瘤坏死因子-α(TNF-α),白细胞介素-6(IL-6),超敏C-反应蛋白(hs-CRP)及血流动力学指标等一般资料均无显著性差异;治疗后治疗组总有效率明显高于对照组(P<0.05);治疗后两组ABI,TBI,足背动脉血流量均明显高于治疗前(P<0.05),治疗组治疗后ABI,TBI,足背动脉血流量均明显高于对照组(P<0.05);治疗后两组的血流动力学指标均较治疗前明显下降(P<0.05);治疗组下降程度明显大于对照组(P<0.05)。在治疗过程中,两组均出现肝功能或肾功能异常,但经过对症治疗后均恢复正常,组间不良反应发生率无差异。结论:血栓通联合前列地尔治疗PDA疗效较好,可改善临床症状和血流动力学情况,抑制炎症反应。Objective： To observe the effectiveness of Xueshuantong combined with prostaglandin E1 in treatment of peripheral arterial disease and its effect on blood rheology. Method： The 91 patients with peripheral arterial disease from July 2013 to June 2014 were divided into two groups according to random number. Patients in treatment group（ 46 cases） were treated with Xueshuantong combined with prostaglandin E1,while patients in control group（ 45 cases） were treated with prostaglandin E1. After treatment,the curative effect of two groups was observed; ankle brachial index（ ABI）, toe brachial index（ TBI）, dorsalis pedis artery blood flow, and hemodynamic indexes were observed before and after treatment in both groups. Result： There was no statistically significant difference between two groups in general data such as patients age,sex,fortain stage,body mass index,pathological changes of lower limbs,ABI,TBI,the dorsalis pedis artery blood flow,tumor necrosis factor-alpha（ TNF-α）,interleukin-6（ IL-6）,hypersensitive C-reactive protein（ hs-CRP） and hemodynamic indexes. After treatment,total effective rate was 95. 65% in treatment group,higher than 82. 61% in control group,with significant difference（ P 〈 0. 05）. After treatment,ABI,TBI,dorsalis pedis artery blood flow were significantly higher than those before treatment in both groups,with significant difference（ P〈 0. 05）,and the above levels in treatment group were significantly higher than those in control group after treatment（ P 〈 0. 05）. After treatment,hemodynamic indexes of two groups were reduced significantly（ P 0. 05）,and the reduction degree in treatment group was significantly greater than that in control group（ P 〈 0. 05）. In the process of treatment,liver or kidney functional abnormities were present in both groups,but they turned back to normal levels after symptomatic treatment,with no difference in incidence of adverse reactions between two groups. Conclusion： Xueshuantong combined with pros

关 键 词：下肢动脉硬化闭塞症 血栓通 前列地尔 血流动力学 

分 类 号：R816.2[医药卫生—放射医学]