调营养心汤治疗亚健康失眠及对血清核转录因子-κB,炎症因子的作用研究  

Effect of Tiaoying Yangxin Decoction in Treatment of Sub-health Insomnia and on Serum Nuclear Transcription Factor Kappa B and Inflammatory Factors

作　　者：刘振华[1,2] 王世军[2] 

机构地区：[1]山东大学附属省立医院,济南250021 [2]山东中医药大学中西医结合基础学院,济南250355

出　　处：《中国实验方剂学杂志》2016年第6期177-180,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：山东省中医药科技发展计划课题(2007-123)

摘　　要：目的:观察调营养心汤对阴虚火旺型亚健康失眠患者的治疗效果并探讨其对血清核转录因子-κB(NF-κB),白细胞介素(IL)-2和IL-6水平的影响。方法:本研究共纳入100例亚健康失眠患者,按数字表法随机分为对照组和观察组各50例;对照组口服艾司唑仑片,1 mg/次,1次/d,临睡前1 h服用;口服谷维素片,2片/次,3次/d。观察组给予调营养心汤治疗,1剂/d,常规水煎煮,分早晚2次内服。两组患者均给予4周观察。比较两组中医症状评分、匹兹堡睡眠质量指数(PSQI)评分;分析两组治疗后4周的临床效果;检测两组患者血清NF-κB,IL-2和IL-6水平。结果:观察组治疗后中医临床症状评分均明显低于对照组(P<0.01);观察组临床显效率为82%,对照组显效率为58%,观察组高于对照组(P<0.05);观察组治疗后PSQI指标评分均明显低于对照组(P<0.01);观察组治疗后血清NF-κB,IL-2和IL-6水平均明显低于对照组,比较差异有统计学意义(P<0.01)。结论:调营养心汤治疗亚健康失眠阴虚火旺证可明显降低临床症状和PSQI指标评分,提高临床疗效,抑制患者血清NF-κB,IL-2和IL-6表达水平。Objective： To observe the clinical efficacy of Tiaoying Yangxin decoction in treating subhealthy insomnia（ Yin-deficiency and fire-hyperactivity syndrome） and its effect on serum nuclear transcription factor-κB（ NF-κB）,interleukin（ IL）-2 and IL-6. Method： One hundred patients with sub-healthy insomnia were randomly divided into control group and observation group by numeric table method（ 50 cases）. Patients of control group were treated with estazolam tablets 1 h before sleeping（ 1 mg / time,qd） and oryzanol tablets（ 2tablets / time,tid） by orally taking. Patients in observation group were treated with Tiaoying Yangxin decoction,one dose / day,bid. Both groups were observed for 4 weeks. After treatment,the traditional Chinese medicine symptom scores and Pittsburgh sleep quality index（ PSQI） scores were compared between two groups. Clinical therapeutic effects were analyzed after treatment in both groups. Serum NF-κB,IL-2 and IL-6 levels were detected in both groups. Result： After treatment,the traditional Chinese medicine symptom scores in observation group were significantly lower than those in control group（ P〈 0. 01）. The total effective rate was 82% in observation group,significantly higher than 58% in control group（ P 〈 0. 05）. Both before and after treatment,the detected scores of PSQI scale in observation group were lower than those of control group（ P 〈 0. 01）. After treatment,levels of serum NF-κB,IL-2 and IL-6 in observation group were significantly lower than those of control group,with statistically significant differences（ P〈 0. 01）. Conclusion： Tiaoying Yangxin decoction for sub-healthy insomnia of Yin-deficiency and fire-hyperactivity syndrome could obviously decrease scores of the clinical symptoms,PSQI,improve the clinical curative effect,and inhibit serum NF-κB,IL-2 and IL-6 levels.

关 键 词：调营养心汤 亚健康失眠 阴虚火旺证 核转录因子-ΚB 白细胞介素-2 白细胞介素-6 

分 类 号：R287[医药卫生—中药学]