清气化痰汤对小儿咳嗽变异性哮喘血清指标和诱导痰指标的影响  

Effect of Qingqi Huatan decoction on serum indicators and induced sputum indicators in children with cough variant asthma

作　　者：黄静[1] 

机构地区：[1]鄂东医疗集团黄石市中医院,湖北黄石435000

出　　处：《海南医学院学报》2016年第10期1020-1023,共4页Journal of Hainan Medical University

基　　金：黄石市科技局项目(2015cx16)~~

摘　　要：目的：分析清气化痰汤对小儿咳嗽变异性哮喘血清指标和诱导痰指标的影响。方法：将2012年8月~2014年12月在本院就诊并治疗的118例咳嗽变异性哮喘患儿纳入研究,按照随机原则将入组患儿分为观察组（n=59）、对照组（n=59）。对照组接受常规治疗,观察组接受常规治疗联合清气化痰汤治疗,对比两组血清、诱导痰及气道解剖学指标差异。结果：观察组治疗后诱导痰嗜酸性阳离子蛋白（ECP）、P物质（SP）、神经生长因子（NGF）、白介素-5（IL-5）、白介素-13（IL-13）水平低于对照组,Toll样受体2（TLR2）水平高于对照组（P〈0.05）;观察组治疗后血清巨噬细胞炎性蛋白-1α（MIP-1α）、嗜酸性粒细胞趋化因子（Eotaxin）、淀粉样蛋白A（SAA）、特异性免疫球蛋白E（SIgE）、总免疫球蛋白E（TIgE）值均低于对照组（P〈0.05）;观察组治疗后血清白三烯B4、白三烯C4、白三烯D4水平均低于对照组（P〈0.05）;观察组治疗后气道腔面积（AI）、气道总横截面积（AO）、气道壁厚度（T）、气道壁面积（WA）、气道壁面积占气道总横截面积百分比（WA%）均小于对照组（P〈0.05）。结论：小儿咳嗽变异性哮喘接受清气化痰汤治疗,可以有效降低患儿全身炎症反应及过敏相关因子产生,逆转患儿气道重塑过程,具有积极的临床意义。Objective：To analyze the effect of Qingqi Huatan decoction on serum indicators and induced sputum indicators in children with cough variant asthma.Methods：A total of 118 cases of children with cough variant asthma were included for study,and all were treated in our hospital from August 2012 to December 2014.According to random principle,included children were divided into observation group（n=59）and control group（n=59）.Control group received conventional treatment,observation group received conventional treatment combined with Qingqi Huatan decoction treatment,and then serum,induced sputum and airway anatomy indicators were compared between two groups.Results：ECP,SP,NGF,IL-5and IL-13 levels in induced sputum of observation group after treatment were lower than those of control group,and TLR2 level was higher than that of control group（P〈0.05）;serum MIP-1α,Eotaxin,SAA,SIgE and TIgE values of observation group after treatment were lower than those of control group（P〈0.05）;serum leukotriene B4,leukotriene C4 and leukotriene D4 levels of observation group after treatment were lower than those of control group（P〈0.05）;AI,AO,T,WA and WA% values of observation group after treatment were lower than those of control group（P〈0.05）.Conclusions：Qingqi Huatan decoction for children with cough variant asthma can effectively reduce systemic inflammatory response and allergy-related factor generation and reverse airway remodeling process,and it has active clinical significance.

关 键 词：咳嗽变异性哮喘 清气化痰汤 诱导痰 

分 类 号：R725.6[医药卫生—儿科]