二甲双胍和有氧运动对高脂诱导肥胖大鼠不同组织ADM蛋白表达的影响  

Effects of Metformin and Aerobic Exercise on ADM Protein Expression Levels in Different Tissues of Obesity Rats

作　　者：薛明淼[1] 王志化[1] 王若梅[1] 王长江[1] 

机构地区：[1]江苏大学附属医院内分泌科,江苏省镇江市212001

出　　处：《医学理论与实践》2016年第6期701-702,共2页The Journal of Medical Theory and Practice

摘　　要：目的:观察二甲双胍、有氧运动分别及联合干预对高脂诱导的肥胖大鼠肾周、附睾脂肪组织ADM表达的影响。方法:选取雄性大鼠70只随机分为普通饮食组(ND组,10只)和高脂饮食组(HD组,60只),16周后从HD组再次随机分为:肥胖组(F,作为对照组)、二甲双胍组(M)、游泳运动组(S)以及二甲双胍联合游泳运动组(MAS)。利用免疫组化方法检测大鼠各组别肾周及附睾脂肪ADM蛋白表达情况。结果:F组肾周及附睾脂肪组织ADM的蛋白表达高于ND组,M组、S组和MAS组肾周及附睾脂肪组织ADM的蛋白表达低于F组。结论:二甲双胍、有氧运动分别及联合干预均可以一定程度下调肾周、附睾脂肪组织ADM的蛋白表达。Objective：To observe the effects of metformin and aerobic exercise on ADM of perirenal adipose tissue（PAT）,epididymis adipose tissue（EAT）in obesity rats fed with high-fat-diet.Methods：70SD rats were randomly divided into normal diet group（ND）with 10 rats and high-fat-diet group（HD）with the remaining 60.The two groups were fed with normal diet and high-fat-diet separately.The HD rats were randomly divided into four groups：Fat group（F）,Metformin group（M）,swimming exercise group（S）,the combination of metformin and swimming exercise group（MAS）.ADM protein expression levels in PAT and EAT were detected using immunohistochemical method.Results：ADM protein expression of group F in PAT and EAT higher than group ND.ADM protein expression of group M,S and MAS lower than group F in PAT and EAT.Conclusion：Metformin,aerobic exercise,the combination of metformin and aerobic exercise can down-regulate ADM protein expression levels in PAT and EAT.

关 键 词：糖尿病 脂肪因子 肾上腺髓质素 二甲双胍 有氧运动 

分 类 号：R332[医药卫生—人体生理学]