急性缺氧对利多卡因致小鼠惊厥作用的影响  

Effects of acute hypoxia on lidocaine-induced convulsion in mice

作　　者：刘玉齐[1] 高学慧[1] 叶海玲[1] 张辉[1] 陈烨[1] 张莹[1] 王丹[2] 

机构地区：[1]徐州医学院麻醉学院2012级2班,江苏徐州221004 [2]徐州医学院麻醉药理学教研室,江苏徐州221004

出　　处：《徐州医学院学报》2016年第1期12-13,共2页Acta Academiae Medicinae Xuzhou

基　　金：江苏省高校自然科学基础研究资助项目（07KJD310219）

摘　　要：目的：观察急性缺氧对利多卡因致小鼠惊厥作用的影响。方法将小鼠随机分为两组：对照组（C组）与急性缺氧组（ H组），腹腔注射80 mg·kg^-1利多卡因，观察各组小鼠的惊厥只数、惊厥率、惊厥潜伏期、惊厥持续时间及惊厥级数。结果与C组相比，H组小鼠惊厥率无明显改变，惊厥潜伏期略缩短，惊厥级数有所下降，但差异无统计学意义，惊厥持续时间显著缩短（P＜0．05）。结论急性缺氧可缩短利多卡因致小鼠惊厥的持续时间。Objective To observe the effects of acute hypoxia on lidocaine -induced convulsion in mice .Methods Kunming mice were randomly divided into two groups：a control group （Group C） and an acute hypoxia group （Group H）.Lidocaine was administered intraperitoneally in the two groups of mice .Then, the convulsion number, convulsion rate, convulsion latency , convulsion duration , and convulsion level were recorded .Results Compared with Group C , there was no significant change in Group H in the convulsion rate .Group H showed slightly declined convulsion latency and level, which however were not remarkably different from the control .The convulsion duration was markedly reduced in Group H in comparison with Group C （P〈0.05）.Conclusion Acute hypoxia can shorten the convulsion duration of lidocaine-induced convulsion in mice .

关 键 词：急性缺氧 利多卡因 惊厥 小鼠 

分 类 号：R332[医药卫生—人体生理学]