呼出气一氧化氮监测与老年支气管哮喘患者与肺功能的相关性研究  

Fractional exhaled nitric oxide monitoring and correlation with pulmonary function in elderly patients with bronchial asthma

作　　者：王玮琴[1] 段玉香[1] 范晔[1] 胡峰[1] 

机构地区：[1]上海交通大学医学院附属同仁医院呼吸内科,上海200050

出　　处：《临床和实验医学杂志》2016年第5期464-466,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨呼出气一氧化氮监测(FeNO)与老年支气管哮喘患者与肺功能的相关性。方法选择老年支气管哮喘患者共69例,检测患者FeNO水平、肺功能与外周静脉血嗜酸性粒细胞(Eos)与中性粒细胞水平,治疗后评价哮喘控制水平,分析不同控制哮喘水平患者FeNO与肺功能的相关性。结果完全控制的患者FeNO水平、Eos、中性粒细胞水平均显著低于部分控制组和未控制组,第一秒用力呼气(FEV1)和第1秒用力呼气量占预计值百分比(FEV1/pred)显著高于部分控制组和未控制组。老年支气管哮喘患者FeNO与EOS和N比率呈明显的正相关(r=0.561,P<0.001;r=0.612,P<0.001),与FEV1和FEV1/pred呈明显的负相关(r=-0.512,P<0.001;r=-0.598,P<0.001)。结论 FeNO在哮喘未控制的老年患者中明显升高,与肺功能存在一定相关性,可用于老年支气管哮喘患者的治疗评估。Objective To investigate the fractional exhaled nitric oxide（ Fe NO） monitoring and correlation with pulmonary function in elderly patients with bronchial asthma. Methods A total of 69 elderly patients with bronchial asthma were collected. Fe NO level,pulmonary function and peripheral blood eosinophils（ Eos） and neutrophils levels were detected after treatment. Asthma control status was evaluated after treatment. Fe NO level and its relevance with pulmonary function in patients with different control levels were analyzed. Results Compared with the patients whose asthma was partially controlled or uncontrolled,Fe NO,Eos and neutrophils levels were significantly lower,FEV1 and FEV1 /pred were significantly higher in patients with complete asthma control. In elderly patients with bronchial asthma,Fe NO was positively correlatedwith EOS and N ratio（ r = 0. 561,P〈0. 001; r = 0. 612,P〈0. 001,respectively）,and negatively correlated with FEV1 and FEV1 / pred（ r=- 0. 512,P〈0. 001; r =- 0. 598,P〈0. 001,respectively）. Conclusion FeN O is significantly increased in elderly patients with uncontrolled asthma and has certain correlation with lung function,therefore FeN O can be used to assess the treatment effectiveness in elderly patients with bronchial asthma.

关 键 词：老年人 支气管哮喘 呼出气一氧化氮 肺功能 

分 类 号：R562.25[医药卫生—呼吸系统]