Plackett-Burnman设计联合Box-Behnken设计-效应面法优化心神宁片的提取工艺  

Optimization of extraction process for Xinshenning Tablets by Plackett-Burnman,Box-Behnken,and response surface methodology

作　　者：宋佳[1,2] 黄飞龙 段树卿 侯超 李云霞 

机构地区：[1]承德医学院,河北承德067000 [2]颈复康药业集团有限公司,河北承德067000

出　　处：《中草药》2016年第3期430-435,共6页Chinese Traditional and Herbal Drugs

摘　　要：目的优选心神宁片的最优提取工艺条件。方法以干膏率及栀子苷、斯皮诺素的转移率为评价指标,以PlackettBurnman设计联合Box-Behnken设计-效应面法对心神宁片的提取工艺进行考察,确定最优提取工艺参数。结果最优提取工艺为7.5倍量70%乙醇,回流提取3次,每次1.5 h。结论优选的醇提工艺经中试验证合理可行,可以用于工业大生产。Objective To optimize the extraction process for Xinshenning Tablets.Methods The extracting condition was optimized by Plackett-Burnman,Box-Behnken,and response surface methodology with the extraction rate,geniposide,and spinosin as indexes.Results The optimal extracting condition was extracting 3 times with 7.5 fold 70% alcohol,1.5 h for each time.Conclusion The optimized process condition is simple and feasible.It can be used in the production.

关 键 词：心神宁片 提取工艺 Plackett-Burnman设计 BOX-BEHNKEN设计 效应面法 干膏率 栀子苷 斯皮诺素 

分 类 号：R284.2[医药卫生—中药学]