深圳市福田区100对母婴及100例育龄妇女麻疹IgG抗体水平分析  

Measles immunoglobulin G antibody levels among 100 pairs of mothers and infants and 100 women of child-bearing age in Futian District,Shenzhen City

作　　者：曹丽[1] 侯红斌[1] 张瑞倚 陈妙芬[1] 方琼[1] 

机构地区：[1]深圳市福田区疾病预防控制中心免疫规划管理科,广东深圳518040

出　　处：《实用预防医学》2016年第4期440-443,共4页Practical Preventive Medicine

基　　金：福田区卫生公益性科研项目(编号FTWS201335)

摘　　要：目的了解母传麻疹抗体的基础水平对新生儿获得被动抗体的影响,为科学地制定预防麻疹措施、降低小月龄婴儿麻疹发病提供依据。方法在深圳市福田区妇幼保健院产科随机选取的100名产妇及所生新生儿及在该院妇保门诊随机抽取的100名育龄妇女作为研究对象,外周静脉采血测定麻疹Ig G抗体水平,对研究对象进行问卷调查。结果血清麻疹Ig G抗体阳性率、保护率、几何抗体平均浓度(GMC)从新生儿组到育龄妇女组、妊娠母亲组逐渐降低,差异均有统计学意义(P<0.05)。不同年龄、户籍、文化程度的妊娠母亲麻疹Ig G抗体水平差异均无统计学意义(P>0.05)。将妊娠母亲按有麻疹自然感染史、有接种疫苗史但无麻疹发病、无麻疹自然感染史且无接种史分为3组,3组麻疹Ig G抗体阳性率及保护率差异均无统计学意义(P>0.05),麻疹自然感染母亲抗体水平高于疫苗接种母亲及无麻疹自然感染且无接种母亲(P<0.05)。母亲麻疹Ig G抗体水平与新生儿麻疹Ig G抗体水平有显著的正相关(r=0.9169,P<0.01)。结论母亲麻疹Ig G抗体水平是影响婴儿麻疹发病率的重要原因,建议对育龄妇女进行麻疹疫苗接种,以提高婴儿胎传抗体水平。Objective To investigate the effect of basal level of maternal- transferred measles antibody on acquirement of passive immunization for newborns so as to provide a basis for scientifically developing measles prevention measures and decreasing the incidence of infants aged 1 - 6 months. Methods We randomly selected 100 puerperae and their neonates from Department of Obstetrics, Maternal and Child Health Hospital of Futian District, Shenzhen City and 100 women of child-bearing age from Department of Maternal Healthcare of the above - mentioned hospital to serve as the research objects. Peripheral venous blood samples were collected to detect the measles IgG antibody level, and a questionnaire investigation was simultaneously conducted among the surveyed objects. Results The positive rate, the protective rate and the geometric mean concentration （GMC） of measles IgG antibody were gradually decreased from the infant group, the group of women of child - bearing age to the gestation group, and the differences were all statistically significant （P 〈 0.05）. No statistically significant differences were found in the measles IgG antibody level among mothers with different ages, residence and educational backgrounds （P 〉 0.05）. All mothers of the gestation group were divided into the group with natural measles infection history, the group with vaccination history but without measles onset and the group without the history of natural measles infection and vaccination, and there were no statistically significant differences in the positive rate of measles antibody IgG and the protective rate among the three groups （P 〉 0.05 ）. The level of measles antibody IgG was higher in the mothers with natural measles infection than in the mothers with vaccination as well as in the mothers without natural measles infection and vaccination （P 〈 0.05）. The correlation coefficient of antibody titer between mothers and infants showed a significantly positive correlation （ r = 0. 9169, P 〈 0.01 ）. Conclusions

关 键 词：母婴 麻疹 抗体水平 

分 类 号：R511.1[医药卫生—内科学]