淋巴细胞计数对社区获得性肺炎患者细胞免疫功能的判断价值  

Value of lymphocyte count in assessing cellular immune function in patients with community-acquired pneumonia

作　　者：赵博[1] 陈莹莹[1] 谭明旗[1] 

机构地区：[1]中国医科大学附属盛京医院呼吸内科,沈阳110004

出　　处：《南方医科大学学报》2016年第2期273-276,共4页Journal of Southern Medical University

摘　　要：目的探讨血常规中淋巴细胞计数对社区获得性肺炎患者细胞免疫功能的判断价值。方法留取我院93例社区获得性肺炎患者(其中53例为非重症,40例为重症)与52例健康体检者的静脉血,行血常规分析及T淋巴细胞绝对计数检测,对比3组受试者血常规中淋巴细胞计数及T淋巴细胞绝对计数的水平,分析相关性。结果社区获得性肺炎患者血常规中淋巴细胞计数及T淋巴细胞绝对计数中CD3^+、CD4^+、CD8^+水平均明显低于对照组(P<0.05),并与血常规中淋巴细胞计数呈显著正相关。建立CD3^+、CD4^+、CD8^+与淋巴细胞计数(L)间回归方程,对照组CD3^+=485.45L+313.48(F=59.68,P<0.01),CD4^+=192.57L+290.11(F=24.62,P<0.01),CD8^+=275.14L+18.04(F=23.46,P<0.01);非重症组CD3^+=564.15L+25.04(F=96.56,P<0.01),CD4^+=381.91L-37.45(F=68.60,P<0.01),CD8^+=165.61L+61.83(F=55.47,P<0.01);重症组CD3^+=565.44L+49.09(F=31.87,P<0.01),CD4^+=332.34L-17.37(F=43.64,P<0.01),CD8^+=223.46L+54.39(F=13.90,P<0.01)。结论社区获得性肺炎患者细胞免疫功能下降,可通过血常规中淋巴细胞计数粗略估计T淋巴细胞计数水平,节约检验成本。Objective To investigate the value of lymphocyte count in assessing cellular immune function in patients with community- acquired pneumonia. Methods Ninety- three patients with community- acquired pneumonia（including 53 nonsevere and 40 severe cases） and 52 healthy adults were examined for routine blood test and T lymphocyte count. Blood lymphocyte counts and absolute T lymphocyte counts were compared among the 3 groups and their correlation was analyzed.Results Compared with the healthy control subjects, patients with community- acquired pneumonia showed significantly lower blood lymphocyte counts and CD3~＋, CD4~＋, and CD8~＋levels（P〈0.05）. CD3~＋, CD4~＋, and CD8~＋levels were positively correlated with blood lymphocyte counts. With blood lymphocyte count as the independent variable（L）, and the regression equations for CD3~＋, CD4~＋, and CD8~＋levels were CD3~＋=485.45L＋313.48（F=59.68, P〈0.01）, CD4~＋=192.57L＋290.11（F=24.62, P〈0.01）,and CD8~＋=275.14L＋18.04（F=23.46, P〈0.01） in the control group; CD3~＋=564.15L＋25.04（F=96.56, P〈0.01）, CD4~＋=381.91L-37.45（F=68.60, P〈0.01）, and CD8~＋=165.61L＋61.83（F=55.47, P〈0.01） in non-severe pneumonia group; and CD3~＋=565.44L＋49.09（F=31.87, P〈0.01）, CD4~＋=332.34L-17.37（F=43.64, P〈0.01）, and CD8~＋=223.46L＋54.39（F=13.90, P〈0.01） in severe pneumonia group. Conclusion Patients with community-acquired pneumonia have decreased cellular immune function. Absolute T lymphocyte count can be estimated by blood lymphocyte count to save the cost of laboratory tests.

关 键 词：血常规 淋巴细胞计数 社区获得性肺炎 T淋巴细胞绝对计数 

分 类 号：R563.1[医药卫生—呼吸系统]