促红素联合多糖铁复合物及左卡尼汀治疗维持性血液透析患者肾性贫血临床研究  

Clinical Study of Erythropoietin Combined with Polysaccharide-iron Compound and Levocarnitine for the Treatment of Maintenance Hemodialysis Patients with Renal Anemia

作　　者：刘延[1] 

机构地区：[1]延安大学附属医院肾内科,陕西延安716000

出　　处：《河北医学》2016年第4期529-532,共4页Hebei Medicine

基　　金：国家自然科学基金;(编号:30572317)

摘　　要：目的:探讨促红素联合多糖铁复合物、左卡尼汀治疗维持性血液透析患者肾性贫血的临床疗效。方法:选取我院68例维持性血液透析肾性贫血患者,随机分为对照组和观察组,每组34例,对照组给予皮下注射促红素;观察组在对照组的基础上加用左卡尼汀静脉缓慢注射,并给予口服多糖铁复合物,治疗时间均为12周。记录治疗前后Hb、Hct、ALB、SF等观察指标变化情况,于疗程结束后比较两组患者贫血改善效果及不良反应的发生情况。结果:经治疗,两组患者的临床症状改善情况均有改善,且观察组明显优于对照组(P<0.05);两组患者治疗后Hb、Hct、ALB、SF等观察指标均有增高,且观察组的增高幅度明显高于对照组(P<0.05);观察组患者不良反应发生率均明显低于对照组(P<0.05)。结论:促红素与多糖铁复合物、左卡尼汀联用治疗维持性血液透析肾性贫血能够显著改善患者的临床症状,与促红素单用治疗相比,联用治疗可减少不良反应的发生。Objective： To investigate the clinical efficacy of erythropoietin combined with polysaccharide-iron compound and levocarnitine for treatment of maintenance hemodialysis patients with renal anemia.Method： 68 cases with renal anemia for maintenance hemodialysis in our hospital were selected and randomly divided into two groups： control group and observation group,with 34 cases in each group. The patients in control group were treated with the subcutaneous injection of erythropoietin,while those in observation group were given intravenous injection of levocarnitine and oral polysaccharide-iron compound on that basis,respectively,with 12 weeks of treatment. The changes of Hb,Hct,ALB and SF were observed and recorded before and after treatment. The efficacy of anemia improvement and adverse reaction of patients were compared between two groups at the end of treatment. Result： After treatment,the clinical symptoms of two groups were improved significantly,but observation group was more obviouse than control group（ P〈0.05）. The indicators of Hb,Hct,ALB and SF increased dramatically in two groups,which was much higher in observation group（ P〈0.05）. The incidence of adverse reactions were much lower than that of control group（ P〈0.05）. Conclusion： Erythropoietin combined with polysaccharide- iron compound and levocarnitine improved the clinical symptoms in treatment of maintenance hemodialysis patients with renal anemia. Compared with the single use of erythropoietin,the combination treatment reduced incidence of adverse reactions.

关 键 词：促红细胞生成素 多糖铁复合物 左卡尼汀 维持性血液透析 肾性贫血 

分 类 号：R692.5[医药卫生—泌尿科学]