3.0T DCE-MRI对宫颈癌的评估价值  

The value of dynamic contrast-enhanced MRI in the assessment of cervical cancer at 3.0T

作　　者：邝菲[1] 颜志平[1] 冯浩[1] 

机构地区：[1]解放军第174医院医学影像科 厦门大学附属成功医院,福建厦门361003

出　　处：《实用放射学杂志》2016年第3期383-387,共5页Journal of Practical Radiology

基　　金：福建省自然科学基金青年创新项目（2014D014）;2014年南京军区医学科技创新课题面上项目（2014MS082）.

摘　　要：目的探讨3．0T动态增强磁共振（DCE—MRI）对宫颈癌各组特征的评估价值。方法156例宫颈癌患者在治疗前行常规MRI及DCE—MRI扫描，在获得病理结果后将宫颈癌患者分成6组（组织学类型，分化程度，FIGO早晚分期，淋巴结状态，肿瘤直径，年龄段）计算时间一信号强度曲线半定量参数，并利用SPSS及R3．1．1软件进行统计学分析。结果鳞癌注射对比剂后30S的强化率（S130s％）及最大增强斜率（Slope）均高于腺癌，FIGO早期宫颈癌的达峰时间（TTP）低于FIGO晚期宫颈癌，FIGO早期宫颈癌的Slope高于FIGO晚期宫颈癌，其余各项分组的各参数之间无明显统计学差异。结论3．0TDCE—MRI的半定量参数可以有效鉴别宫颈鳞癌与腺癌及FIGO早／晚分期宫颈癌，利用Slope鉴别宫颈鳞癌与腺癌的价值高于S130s％，TTP与Slope鉴别FIGO早／晚分期宫颈癌的价值相当。Objective To evaluate the value of dynamic contrast-enhanced MRI （DCE-MRI） in the assessment of cervical cancer with different features. Methods A cohort study of 156 cervical cancer patients underwent routine MRI and DCE-MRI scanning on 3.0T MR unit. The semi-quantitative parameters from time-signal curve of DCE-MRI were divided into the following groups： 1 ） squamous carcinoma and adenocarcinoma. 2） different pathologic grades of cervical cancer （G1,G2,G3）. 3） early stage （FIGOⅠb/Ⅱa） tumor and advanced tumor （FIGO Ⅱb, Ⅲ and Ⅳ）. 4） cervical cancer with different lymph node status （no/yes）. 5） cervical cancer with different tumor size （greatest diameter 〈2 cm, 2 4 cm, 〉4 cm）. 6） cervical cancer with different age range. Statistical analysis was performed with the data analysis program SPSS and R3. 1. 1. Results There was a statistically significant difference between the squamous carcinoma and adenocarcinoma in the SI30s% and Slope,as well as between the tumor FIGO early and advanced stage in TTP and Slope. There was no significant difference among other groups. Conclusion The semi-quantitative parameters from timesignal curve of DCE-MRI can be used to differentiate histologic type and FIGO early/advanced stage of cervical cancer. The diagnostic accuracy may be high for Slope for histologic type differentiation, and the diagnostic accuracy is equal for TTP and Slope in differenti- ation of FIGO early and advanced stage of cervical cancer.

关 键 词：动态增强磁共振成像 宫颈癌 半定量参数 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.33[医药卫生—诊断学]