血清亲环素A与慢性心力衰竭的关系  

Relationship Between Blood Levels of Cyclophilin A and Chronic Heart Failure

作　　者：宣玲[1] 唐碧[1] 康品方[1] 张恒[1] 王洪巨[1] 赵皓[2] 

机构地区：[1]蚌埠医学院第一附属医院心血管科,安徽省蚌埠市233004 [2]蚌埠医学院第一附属医院中心实验室,安徽省蚌埠市233004

出　　处：《中国循环杂志》2016年第3期223-225,共3页Chinese Circulation Journal

基　　金：安徽省高等学校自然科学研究项目(KJ2015B026by);安徽省科技攻关项目(1501041154);2016年高校学科(专业)拔尖人才学术资助重点项目(gxbj ZD2016072)

摘　　要：目的:探讨血清亲环素A与慢性心力衰竭(CHF)的关系。方法:入选CHF患者166例(CHF组),按纽约心脏协会(NYHA)心功能分级标准,心功能I、Ⅱ、Ⅲ及Ⅳ级患者分别为37、39、46及44例。同时选取健康者52例为正常对照组。联合检测两组血清中亲环素A、B型利钠肽(BNP)及高敏C-反应蛋白(hs-CRP)水平,并进行比较分析。结果:CHF组血清中亲环素A、BNP和hs-CRP水平均高于正常对照组[亲环素A:(5.11±2.43)ng/ml v(s2.28±0.61)ng/ml;BNP:(385.65±184.06)pg/ml vs(90.37±18.44)pg/ml;hs-CRP:(11.74±5.44)mg/L vs(5.99±1.14)mg/L],差异均有统计学意义(P均<0.05)。在两组不同级别心功能患者间,随着心功能级别的加重,血清中亲环素A、BNP和hs-CRP水平均呈增加趋势,除心功能I级患者血清亲环素A和hs-CRP较正常对照组差异无统计学意义外(P均>0.05),其他差异均有统计学意义(P均<0.05)。Pearson相关分析,CHF组血清中亲环素A与BNP、hs-CRP水平均呈正相关(r=0.838,P<0.01;r=0.755,P<0.01)。结论:血清亲环素A水平在CHF患者中升高,且与心功能分级有明显关系,这可能对CHF诊断和心力衰竭程度的评估有一定作用。Objective： To explore the relationship between blood levels of cyclophilin A（CyP A） and chronic heart failure（CHF）.Methods： A total of 166 CHF patients were enrolled as CHF group, according to NYHA classification, it was further divided into 4 sub-groups： Class I, n=37, Class II, n=39, Class III, n=46 and Class IV, n=44. In addition, there was a Normal control group, n=52. Blood levels of CyP A, B-type natriuretic peptide（BNP） and high sensitivity C-reactive protein（hs-CRP） were examined and compared among different groups. Results： Compared with Normal control group, CHF group had elevated Cy PA（5.11 ± 2.43） ng/ml vs（2.28 ± 0.61） ng/ml, BNP（385.65 ± 184.06） pg/ml vs（90.37 ± 18.44） pg/ml and hs-CRP（11.74 ± 5.44） mg/L vs（5.99 ± 1.14） mg/L, all P〈0.05. As increased severity of NYHA classification, blood levels of CyP A, BNP and hs-CRP between 2 subgroups had the increasing trend accordingly, all P〈0.05; while there was an exception： blood levels of CyP A and hs-CRP were similar between Class I subgroup and Normal control group, all P〈0.05. Pearson correlation analysis indicated that blood levels of CyP A were positively related to BNP and hs-CRP in CHF patients（r=0.838, P〈0.01 and r=0.755, P〈0.01）. Conclusion： Blood levels of Cy PA were elevated in CHF patients and it＇s obviously related to NYHA classification, which might have certain effects on CHF diagnosis and evaluation.

关 键 词：亲环素A 利钠肽 脑 C反应蛋白质 心力衰竭 

分 类 号：R54[医药卫生—心血管疾病]