慢性阻塞性肺疾病患者报告临床结局量表的条目筛选  

Item Screening of Patient-reported Outcomes Instrument for Chronic Obstructive Pulmonary Disease

作　　者：李敏捷[1] 吕宏梅[2] 罗艳虹[1] 刘晓英[2] 张岩波[1] 

机构地区：[1]山西医科大学公共卫生学院卫生统计教研室,山西太原030001 [2]山西医科大学护理学院,山西太原030001

出　　处：《中国呼吸与危重监护杂志》2016年第2期105-108,共4页Chinese Journal of Respiratory and Critical Care Medicine

基　　金：国家自然科学基金(编号:81273180)

摘　　要：目的研制适合中国人群的慢性阻塞性肺疾病(简称慢阻肺)患者报告临床结局(PRO)量表,为临床疗效评价提供工具。方法遵循国际PRO量表研制的流程规范,建立条目池,形成初量表。用初量表在太原市的5所医院和社区卫生中心对150个样本(慢阻肺患者100份,健康人50份)进行调查,运用离散趋势法、因子分析法、相关系数法、克朗巴赫α系数法和项目反应理论等5种方法对量表条目进行条目筛选和调整,形成终量表。结果终量表涉及生理领域、心理领域、社会领域、治疗领域4个领域,包含特异性症状、全身症状、独立性、焦虑、抑郁、疾病认知、疾病对社会活动的影响、社会支持、依从性、药物不良反应、满意度11个维度,共计52个条目。结论研究设计的慢阻肺患者PRO终量表基本符合理论框架,适合中国慢阻塞肺患者,可反映患者生命质量的内涵。Objective To develop a patient-reported outcomes scale of chronic obstructive pulmonary disease used for Chinese,thus offering tools for clinical efficacy assessment. Methods According to the development standard of International Patient-Reported Outcomes,the item pool was established and the preliminary scale was prepared. Then,100 patients with chronic obstructive pulmonary disease and 50 healthy subjects were face-to-face interviewed with preliminary scale by well-trained investigators. Those copies were collected,surveys were analyzed and items were selected with 5 methods including measure of discrete tendency method,factor analysis,correlation coefficient method,Cronbach＇s alpha coefficient method and item response Theory. Finally,the final scale was gained. Results The eventual scale contains 4 areas（ physiological dimain, psychological dimension, social dimension,treatment）,11 dimensions（ specific symptoms,general symptoms,individual,anxiety,depression,disease cognization, disease influence on social pctivity, social support, compliance, drug adverse reaction,satisfactory）,and 52 items. Conclusion The ultimate scale coincides with the theoretical framework and reflects the connotation of the quality of life of patients with chronic obstructive pulmonary disease.

关 键 词：慢性阻塞性肺疾病 患者报告临床结局 条目筛选 

分 类 号：R563.9[医药卫生—呼吸系统]