胺碘酮与伊布利特对老年转复消融术后持续性心房颤动的临床疗效评价  

Clinical efficacy of amiodarone and ibutilide on persistent atrial fibrillation in elderly patients after ablation

作　　者：丁云 孙建国 吴建荣 张晓萍[4] 

机构地区：[1]浙江绿城心血管病医院药剂科,杭州313000 [2]浙江绿城心血管病医院心内科,杭州313000 [3]浙江绿城心血管病医院骨科,杭州313000 [4]杭州民生药业有限公司,杭州310011

出　　处：《中国临床药理学杂志》2016年第6期570-572,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江省医药卫生科技基金资助项目(201482726)

摘　　要：目的观察胺碘酮与伊布利特对老年转复消融术后持续性心房颤动的临床疗效。方法 104例持续性老年心房颤动患者,按照随机数字表法分为试验组及对照组,各52例。试验组给予胺碘酮150 mg,生理盐水稀释至20 m L后,30min内静脉推注完毕。对照组给予伊布利特1 mg,生理盐水稀释至20 m L后,10min内静脉推注完毕。比较2组患者心房颤动转复情况,并观察其不良反应发生情况。结果对照组临床总有效率为92.3%,显著高于试验组的59.6%(P<0.05),其转复时间显著低于试验组,且QTc延长幅度低于试验组(P<0.05)。对照组和试验组不良反应发生率分别为17.3%,13.5%,差异无统计学意义(P>0.05)。结论伊布利特可有效保证老年心房颤动患者射频消融术后早期转复,具有较快的起效时间及良好的安全性。Objective To doserve the clinical efficacy of amiodarone and ibutilide on persistent atrial fibrillation（ AF） in elderly patients after ablation,and analyze their clinical values. Methods A total of 104 cases of persistent elderly AF patients were randomly divided into treatment group and control group,52 cases in each group. Patients in treatment group were given amiodarone 150 mg,diluted to normal saline 20 m L,intravenous injection for 30 min. Patients in control group were given ibutilide 1 mg,diluted to normal saline 20 m L,intravenous injection for10 min. AF cardioversion and the adverse reaction were observed in two groups. Results Total effective rate in control group was 92. 3%,significantly higher than 59. 6% in treatment group（ P〈0. 05）. The QTc extension time of control group was significantly lower than that of treatment group（ P〈0. 05）. The incidence rates of control group and treatment group were 17. 3%, 13. 5%, with no statistical significance（ P〈0. 05）. Conclusion Ibutilide can effectively ensure the early cardioversion of AF after radiofrequency ablation in elderly patients with faster onset time and good safety.

关 键 词：胺碘酮 伊布利特 转复消融术 持续性房颤 

分 类 号：R541.7[医药卫生—心血管疾病]