高尿酸血症患者血清白介素-6和转化生长因子-β1水平及应用非布司他治疗前后的变化  

Study on the level of serum IL-6,TGF-β1 in hyperuricemic patients and after Febuxostat treatment

作　　者：张彩香[1] 林章梅 梁艳玲[2] 李意[1] 王会中[2] 赵蕾[2] 王平[2] 曲建昌[2] 李丽[2] 徐锌 姜姗姗[2] 祝开思[1] 

机构地区：[1]南方医科大学研究生学院,广州510515 [2]解放军第305医院内分泌科

出　　处：《中国糖尿病杂志》2016年第3期250-253,共4页Chinese Journal of Diabetes

摘　　要：目的观察血尿酸(SUA)与白介素—6(IL-6)、转化生长因子—β1(TGF-β1)的关系,及非布司他降SUA治疗的效果。方法选取高尿酸血症(HUA)男性患者110例,分为无症状HUA者(sHUA组)60例和痛风者(Gout组)50例,另选取健康对照(NC)组60名。检测血清TGF-β1、IL-6、血肌酐(Scr)、SUA、高敏C反应蛋白(hsC-RP)及血脂等生化指标,采用改良的MDRD公式计算GFR。结果 (1)Gout组血清TGF-β1、IL-6、Scr、SUA、hsC-RP、TG、BMI及SBP均高于NC组,GFR、HDL-C低于NC组(P<0.05);Gout组IL-6和hsC—RP高于sHUA组(P<0.05);sHUA组TGF-β1、IL-6、SUA、TG、高于NC组,HDL-C低于NC组。(2)血清IL-6与SUA、TGF-β1呈正相关(r=0.466、0.360,P=0.000、0.001);TGF-β1与SUA呈正相关(r=0.266,P=0.014)。(3)经非布司他降SUA治疗后,TGF-β1、IL-6、SUA下降(P=0.000)。结论 HUA人群合并微炎状态,且促纤维化炎症因子TGF-β1升高;非布司他降SUA效果好,可有效减轻HUA引起的炎症反应。Objective To investigate the relationship of IL-6,TGF-β1 and uric acid in hyperuricemic patients and the effect of febuxostat in lowering uric acid.Methods A total of 110 male cases of hyperuricemia（HUA） were divided into symptomless hyperuricemia group（sHUA,n = 60） and gout group（gout,n=50）.60 healthy volunteers served as normal controls（NC group）.TGF- β1,IL-6,Scr,SUA and hsC-RP were detected in all subjects.GFR was calculated by formula of MDRD.Results（l）The serum TGF-β1,IL-6,Scr,SUA,hsC-RP,TG,BMl and SBP in Gout group were higher,and GFR,HDL-C were lower than those in NC group（P〈0.05）;IL-6 and hsC-RP in Gout group were higher than those in sHUA group;TGF-β1,IL-6,SUA,TG in sHUA group were higher,HDL-C were lower than those in NC group.（2）The correlation analysis showed that serum IL-6 was positively correlated with Scr,SUA and TGF-β1（r= 0.466,0.360,F=0.000,0.001）;serum TGF-β1 was positively correlated with SUA（r=0.266,P =0.014）.（3） The levels of TGF-β1,IL-6 and SUA notably decreased after febuxostat treatment（P =0.000）.Conclusion Hyperuricemic patients presented with micro-inflammatory and higher level of stimulate fibrosis factor TGF-β1.Febuxostat treatment can effectively reduce the level of uric acid and inhibit the corresponding inflammation.

关 键 词：高尿酸血症 白介素-6 转化生子因子-β1 非布司他 

分 类 号：R589.7[医药卫生—内分泌]