间充质干细胞成骨分化调控蛋白研究  

Progress of Osteogenetic Differentiation-mediated Proteins of Mesenchymal Stem Cells

作　　者：江恒君 沈云芸 朱侃[1] 李敏超[1] 曾群力[1] 

机构地区：[1]浙江大学医学院,浙江省生物电磁学重点研究实验室,杭州310058

出　　处：《中国细胞生物学学报》2016年第2期235-242,共8页Chinese Journal of Cell Biology

基　　金：高等学校博士学科点专项科研基金(博导类)(批准号:20110101110104);国家重点基础研究发展计划(973计划)(批准号:2011CB503702);国家自然科学基金(批准号:31170799)资助的课题~~

摘　　要：间充质干细胞具有分化成骨的潜能,已逐渐成为骨损伤临床治疗的种子细胞。研究表明,生物化学试剂和物理因素均可诱导间充质干细胞的成骨分化,并且一些配体蛋白和转录因子参与了此过程。该文综述了近十年来关于间充质干细胞成骨分化调控蛋白的研究,以期为间充质干细胞成骨分化的临床应用提供理论依据和科学指导。Mesenchymal stem cells（MSCs） are becoming ideal seed cells for clinical treatment of bone injuries due to their potential of osteogenesis. Osteogenetic differentiation of mesenchymal stem cells could be induced by the biological and chemical reagents and physical factors. During the differentiation, some ligands and transcription factors were involved in this process. In this review, we summed up studies of osteogenetic differentiation-mediated proteins of MSCs based on the literatures reported in recent 10 years in order to provide a basis and scientific guidance for the clinical application of mesenchymal stem cells.

关 键 词：间充质干细胞 成骨细胞 分化调控蛋白 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]