EV71型重症手足口病患儿血浆可溶性髓系细胞触发受体-1及炎症介质水平的变化  

Changes of plasma soluble triggering receptor-1 and inflammatory mediators in children with severe hand foot and mouth disease of EV71

作　　者：江明荣[1] 周曙明[1] 黄循斌[1] 谢晓彬[1] 陈柏良[1] 

机构地区：[1]广东省深圳市龙岗中心医院,广东深圳518116

出　　处：《中国医药导报》2016年第8期84-87,共4页China Medical Herald

基　　金：广东省龙岗区科技计划医疗卫生项目(YS2013120)

摘　　要：目的探讨EV71型重症手足口病血浆可溶性髓系细胞触发受体-1及炎症介质水平的变化情况。方法选取2013年12月-2015年6月在深圳市龙岗中心医院临床诊断感染EV71的90例手足口病患儿（感染组）和50例同期体检健康儿童（对照组）作为研究对象，根据临床分型将感染组分为普通组（32例）和重症组（58例）。比较各组及感染组急性期和恢复期血浆sTREM-1及TNF-α、IL-1β、IL-8、IL-4、IL-10水平。结果与对照组比较。感染组血浆sTREM-1及TNF-α、IL-1β、IL-8、IL-4、IL-10水平明显升高，差异均有统计学意义（P〈0．05）；感染组急性期血浆sTREM-1及TNF-α、IL-1β、IL-8、IL-4、IL-10水平明显高于恢复期，差异均有统计学意义（P〈0．05）；与对照组比较，普通组、重症组急性期及恢复期血浆sTREM-1及TNF-α、IL-1β、IL-8、IL-4、IL-10水平均明显升高，差异均有统计学意义（P〈0．05）；重症组急性期及恢复期血浆sTREM-1及TNF-α、IL-1β、IL-8、IL-4、IL-10水平均明显高于普通组，差异均有统计学意义（P〈0．05）。结论sTREM-1在EV71型重症手足口病发病过程中可能起促炎作用，该病与抗炎与促炎介质失衡有关。Objective To investigate the changes of plasma soluble triggering receptor-1 and inflammatory mediators in children with severe hand foot and mouth disease of EV71. Methods The 90 children with hand foot mouth disease of EV71 diagnosed clinically in Longgang Central Hospital of Shenzhen from December 2013 to June 2015 （infection group） and 50 cases of healthy children （control group） during the same period were selected as research subjects, the infection group were divided into common group （32 cases） and severe group （58 cases） according to the clinical classi- fication. Levels of plasma sTREM-1, TNF-α, IL-1β, IL-8, IL-4 and IL-10 in each group and children with different stages of the infection group were compared. Results Compared with the control group, the levels of plasma sTREM-1, TNF-α, IL-1β, IL-8, IL-4 and IL-10 in infection group were significantly higher than the control group, the differ- ences were statistically significant （P 〈 0.05）; the levels of plasma sTREM-1, TNF-α, IL-1β, IL-8, IL-4 and IL-IO in children at acute stage of infection group were significantly higher than the recovery period, the differences were statis- tically significant （P 〈 0.05）; compared with the control group, the levels of plasma sTREM-1, TNF-α, IL-1β, IL-8, IL-4 and IL-10 were significantly increased in normal group, children at severe acute stage and recovery stage of the infection group, the differences were statistically significant （P 〈 0.05）; the levels of plasma sTREM-1, TNF-α, IL-1β, IL-8, IL-4 and IL-10 in children at severe acute stage and recovery stage were significantly higher than the normal group, the differences were statistically significant （P 〈 0.05）. Conclusion STREM-1 may play a pro-inflammatory role in the pathogenesis of severe hand foot mouth disease in type EV71, which is related to the imbalance of anti-inflam- matory and pro-inflammatory mediators.

关 键 词：肠道病毒71型 重症手足口病 可溶性髓系细胞触发受体-1 炎症介质 

分 类 号：R512.5[医药卫生—内科学]