甲磺酸多拉司琼与地塞米松磷酸钠在两种输液中的配伍稳定性考察  

Stability Study of Dolasetron Mesylate and Dexamethasone Sodium Phosphate Admixture in Common Infusions

作　　者：何光照 雷凯[2] 张程亮[2] 薛宏波 

机构地区：[1]常州市肿瘤医院药剂科,常州213032 [2]华中科技大学同济医学院附属同济医院药学部,武汉430030

出　　处：《药学与临床研究》2016年第2期128-130,共3页Pharmaceutical and Clinical Research

摘　　要：目的:考察甲磺酸多拉司琼与地塞米松磷酸钠在两种输液中的配伍稳定性。方法:模拟临床操作,在室内室温(25℃)不避光环境下,临床常用量甲磺酸多拉司琼与地塞米松磷酸钠分别在5%葡萄糖注射液(5%GS)和0.9%氯化钠注射液(NS)中配伍,在0 h(配制后5 min内)、3、6、24 h对配伍液的物理稳定性(外观、不溶性微粒)、化学稳定性(p H值、浓度)进行考察。结果:配伍液在24 h内保持无色、澄清,未见气泡、絮状物和沉淀产生,不溶性微粒、p H值与配伍液中两药浓度变化符合配伍要求,且色谱图均未发现异常色谱峰。结论:在室内室温(25℃)不避光时,甲磺酸多拉司琼注射液和注射用地塞米松磷酸钠于100 m L 5%GS或0.9%NS中,24 h内配伍稳定。Objective: To inves tigate the stability of admixture of dolasetron mesylate and dexamethasone sodium phosphate(DSP) in common infusions. Methods: Simulating clinical practice, at ambient conditions(25 ℃), dolasetron mesylate and DSP were dissolved into 5% glucose(GS) and 0.9% sodium chloride(NS), respectively. Their physical(appearance and insoluble particles) and chemical(p H and concentraton) stability were investigated at 0 h(within 5 min after admixture), 3 h, 6 h, and 24 h. Results: The admixtures of dolasetron mesylate and DSP in common infusions remained colorless and clear. No visible bubble, floc or precipitation et al was observed. Particulate matter, p H and concentrations of the two components met the standard of stability. Conclusion: At ambient conditions(25 ℃), the admixtures of 100 mg dolasetron mesylate injection and 10 mg or 20 mg DSP for injection in 100 m L 5%GS or 9% NS, are stable within 24 hours.

关 键 词：甲磺酸多拉司琼 地塞米松磷酸钠 配伍 稳定性 

分 类 号：R969.2[医药卫生—药理学]