双氯芬酸钠栓和坦索罗辛及两药联用治疗输尿管远端结石的疗效比较  

Comparison of the Efficacy of Diclofenac Sodium, Tamsulosin and Their Combination for the Treatment of Distal Ureteral Calculus

作　　者：杜广建[1] 艾克拜尔.阿布拉 袁留亚 吴冠伟[1] 阿不都.赛买提 阿里木.太来提 张涛[1] 木拉提.马合木提 

机构地区：[1]新疆医科大学第二附属医院泌尿外科,乌鲁木齐830028

出　　处：《药学与临床研究》2016年第2期151-153,共3页Pharmaceutical and Clinical Research

摘　　要：目的:比较双氯芬酸钠栓和坦索罗辛及两药联用治疗输尿管远端结石的效果。方法:将输尿管远端结石患者150例,随机分为A组、B组和C组,各50例,A组给予双氯芬酸钠栓治疗,B组给予坦索罗辛胶囊治疗;C组给予两种药物联合治疗。以结石排出及疼痛发作情况为主要的比较指标,以结石排出或治疗2周为观察终点。结果:A、B、C 3组结石排出例数分别为30例、32例、43例;A、B、C组用药后肾绞痛的发作例数分别为14例、17例、6例,均具有统计学差异(P<0.05);A、B、C组不良反应发生例数分别为5例、6例、8例,无统计学差异(P>0.05)。结论:双氯芬酸钠栓和坦索罗辛两种药物联用时可以提高排石效果,缩短排石时间,减少肾绞痛发作,而且不良反应并没有明显增加,建议两种药物联用治疗输尿管远端结石。Objective: To compare the effects of diclofenac sodium and tamsulosin for the treatment of distal ureteral calculi. Methods: A total of 150 patients with distal ureteral calculi were randomly divided into A(diclofenac sodium suppository), B(tamsulosin capsule) and C(both) groups with equal cases. The main comparison indexes were stone discharge and pain, the observation endpoint was stone removal or treatments for two weeks. Results: In A, B and C groups, the calculus expulsion cases were respectively30, 32 and 43, the cases occurred renal colic episodes were respectively 14, 17 and 6, both with significant differences(P<0.05); while the cases of adverse reactions were respectively 5, 6 and 8, with no statistical difference(P>0.05). Conclusion: Combination of the two drugs can improve the removal of distal ureteral alculi, reduce lithagogue time and renal colic without the increase of adverse reactions. Therefore,combination of the two drugs for treatment of distal ureteral calculi is suggested.

关 键 词：输尿管远端结石 双氯芬酸钠栓 坦索罗辛胶囊 

分 类 号：R983.2[医药卫生—药品]