蒲元和胃治疗慢性萎缩性胃炎并胃黏膜糜烂的效果  

EFFICACY OF PUYUANHEWEI CAPSULES IN THE TREATMENT OF CHRONIC ATROPHIC GASTRITIS WITH EROSION

作　　者：姜坤[1] 刘希双[1] 孙学国[1] 张凌云[1] 郝正魁[2] 张廷光[3] 

机构地区：[1]青岛大学附属医院东区消化内科,山东青岛266071 [2]威海市立医院急诊科 [3]邹城市人民医院消化内科

出　　处：《青岛大学医学院学报》2016年第1期14-17,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨蒲元和胃治疗慢性萎缩性胃炎(CAG)并胃黏膜糜烂的效果。方法选择经胃镜及病理诊断明确的CAG并胃黏膜糜烂的病人83例,随机分为PYHW组41例,对照组42例,PYHW组给予蒲元和胃及外观、味道、剂量与替普瑞酮相同的安慰剂治疗,对照组给予替普瑞酮及外观、味道、剂量与蒲元和胃相同的安慰剂治疗,记录每组病人病情的改变情况,并通过定标活检获取治疗前后两组病人胃黏膜糜烂处的标本,采用免疫组织化学技术测定所取标本表皮生长因子(EGF)、EGF受体(EGFR)的表达情况。结果疗程结束后,PYHW组病人上腹胀、嗳气、食欲不振的治疗效果优于对照组,差异有显著性(Z=-2.133^-1.971,P<0.05);而治疗后黏膜萎缩及糜烂情况与对照组比较差异无显著性(P>0.05)。PYHW组治疗后EGF、EGFR表达较对照组明显增加(t=2.77、3.61,P<0.05)。结论蒲元和胃可明显改善CAG并胃黏膜糜烂病人的临床症状,其治疗机制与EGF及EGFR表达增加有关。Objective To assess the efficacy of PUYUANHEWEI （PYHW） for chronic atrophic gastritis （CAG） with erosion. Methods Eight～three patients confirmed by gastroscopy and pathology as having CAG with erosion were selected and divided into PYHW group （n=41） and control group （n = 42） at random. The patients in PYHW group were given PYHW and placebo like Teprenone in appearance, taste and dosage those in the control group received Teprenone and placebo like PYHW. The patients＇ conditions in both groups were recorded everyday, and a biopsy of gastric mucosa was done. The expressions of epi dermal growth factor （EGF） and EGF receptor in the samples obtained were detected using immunohistochemical technique. Re- suits After treatment, the symptoms of epigastric distention, belch, and anepithymia were much better improved in the PYHW group versus the control （Z=2.133-- 1.971, P 〈0.05）, while the difference in gastric m ucosa was not significant. The mean increasing expression of epidermal growth factor （EGF） and epidermal growth factor receptor （EGFR） from erosion mucosa in PYHW group were higher than that in the control group （t =2.77,3.61 ;P〈0.05）. Conclusion PUYUANHEWEI can obvious- ly improve the symptoms of patients with chronic atrophic gastritis complicating erosion of gastric mucosa. Its therapeutic mecha- nism is associated with the increase of expressions of epidermal growth factor and epidermal growth factor receptor.

关 键 词：蒲元和胃 表皮生长因子 受体 表皮生长因子 胃炎 萎缩性 

分 类 号：R259[医药卫生—中西医结合]