中药与肝脏药物代谢酶之间的相互作用  

Interactions between drug metabolizing enzymes and traditional Chinese medicine

作　　者：马增春[1] 王宇光[1] 谭洪玲[1] 梁乾德[1] 肖成荣[1] 汤响林[1] 高月[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京市100850

出　　处：《世界华人消化杂志》2016年第7期994-1001,共8页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;Nos.81274127;81130067;国家重点基础研究发展计划基金资助项目;No.2012CB518402~~

摘　　要：肝脏药物代谢酶是决定中药复方体内过程的关键因素,复方中化学成分对药物代谢酶的抑制或诱导作用是中药复方在药动学层次上产生相互作用的主要机制.本文首先建立中药配伍与肝脏药物代谢酶的相互作用技术,在有效组分、有效部位和饮片三个层次发现中药与肝脏药物代谢酶之间的相互作用,筛选发现中药复方中对肝脏药物代谢酶的诱导或抑制成分,探索肝脏药物代谢酶对中药成分代谢作用的具体亚型,结合中药复方作用的体内过程,系统阐述中药成分与机体之间的相互作用,为中药配伍、药效和安全性评价提供理论依据,为建立基于肝脏代谢酶表达方剂整体性研究的新模式提供技术支撑.Drug metabolizing enzymes are key in determining the fate of drugs,and their inhibitory or inducing effects are the primary mechanism of drug interactions.In this paper,we discuss the method for detecting the interactions between drug metabolizing enzymes and traditional Chinese medicine;identify the possible substrates of drug metabolizing enzymes at the level of active ingredients,effective group and decoction pieces;analyze the effect of traditional Chinese medicine on drug metabolizing enzymes at the levels of mRNA,protein and the enzyme activity,as well as the inhibitory or inducing effects of chemical components on metabolizing enzymes;identify the specific subtype;and clarify the metabolic processes,the basis of compatibility,and interactions between drug metabolizing enzyme and traditional Chinese medicine,with an aim to provide the basis for compatibility and rational administration in clinical practice.

关 键 词：中药 肝脏药物代谢酶 配伍 相互作用 

分 类 号：R285.5[医药卫生—中药学]