复发性假丝酵母菌外阴阴道病致病菌种分析  

Species analysis of Candida isolates came from recurrent vulvovaginal candidiasis patients

作　　者：祁文瑾[1] 陈卓[1] 许妙玲[2] 

机构地区：[1]昆明医科大学第一附属医院产科,昆明650032 [2]昆明医科大学第一附属医院妇科,昆明650032

出　　处：《安徽医科大学学报》2016年第4期555-557,共3页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81160076);云南省中青年学术技术带头人后备人才培养项目(编号:2012HB029);云南省医学学科带头人培养项目(编号:D-201225)

摘　　要：目的对复发性假丝酵母菌性外阴阴道病(RVVC)患者不同发病时期致病菌种进行分析,为RVVC的有效治疗提供病原学研究资料。方法以科玛嘉显色培养基和VITEK 2酵母菌鉴定卡鉴定妊娠与非妊娠RVVC患者致病菌种差异,同期假丝酵母菌性外阴阴道病(VVC)患者为对照。结果非孕RVVC复发患者及妊娠VVC患者致病非白假丝酵母菌检出率均显著高于非孕VVC患者(P<0.05);妊娠RVVC复发患者中自假丝酵母菌比例虽较妊娠RVVC初发和妊娠VVC患者有所降低,但三组间白似丝酵母菌构成比差异无统计学意义。结论假丝酵母菌的复发和再感染均在RVVC的发生中发挥作用,妊娠状态可能增加阴道非白假丝酵母菌感染几率。Objective To identify the Candida species isolated from recurrent vulvovaginal candidiasis （RVVC）pa- tients, and provide etiologic datum of RVVC. Methods All Candida isolates, including those from vulvovaginal candidiasis （VVC） and RVVC patients, were identified by using CHROMagar chromogenic medium and VITEK2 yeast identification kits. Results The proportions of nonalbicans species from nonpregnant RVVC relapse patients and pregnant VVC patients were both significantly higher than those from nonpregnant VVC patients （ P 〈 0. 05 ）. Among pregnant patients, the percentage of C. albicans isolated from RVVC relapse was couer, but there was no significant difference of C. albieans species percentage between RVVC and VVC patients. Conclusion RVVC may be related to the recurrence of same Candia species and the reinfection of different Candia species. Pregnant women may be more inclinable to suffer from disorder caused by nonalbicans species.

关 键 词：假丝酵母菌病 外阴阴道 妊娠 病原学 

分 类 号：R711.72[医药卫生—妇产科学]